Purpose
Benign Pancreatic Hyperenzymemia (BPH) is a condition characterized by persistent levels of serum amylase and lipase above the upper normal limits without clinical evidence of pancreatic symptoms [1].
Firstly described by Warshawand Lee in 1978 [2], subsequently, Gullo considered this condition as benign because without imaging (ultrasound and computed tomography) evidence of organic pancreatic disease [1].
However, in recent years, several studies using magnetic resonance cholangiopancreatography with secretin stimulation (s-MRCP) have been published proving the evidence of various pancreatic changes (ranging from 9 to 70...
Methods and materials
We have enrolled 252 asymptomatic patients with an abnormal increase of serum pancreatic enzymes (mean age: 51 ± 14 y/o; M:F = 133:119). All of them underwent s-MRCP at our Institution from February 2007 to November 2018.
We excluded patients with pancreatic symptoms, previous GI surgery or ERCP and other conditions that could cause hyperenzymemia (macroamylasemia, coeliac disease, renal impairment, chronic viral hepatitis, salivary hyperamylasaemia).
All the examinations have performed with a 1.5 T scanner and an 8-channel phased-array surface coil according to the same...
Results
About 252 patient, 172 subjects (68%) had an abnormal increase of lipase and amylase, 57 (22%) of amylase and 23 (9%) of lipase.
76% of the studied patients had had different pancreatic anomalies at s-MRCP.
MRI signs of chronic pancreatitis were detected in 168 (65,7%) subjects, of whom 108 were mild and 60 moderate according to the Cambridge classification (Fig. 1) [11].
Secondary, sphincter of Oddi dysfunction (SOD) was founded in 80 patients (31,7%); this is a term used to indicate abnormal motility of the...
Conclusion
The main result of the study is the presence of pancreatic abnormalities at s-MRCP in 76% of the subjects; according to those observed in other previous studies [3-10]. Therefore, based on our experience, s-MRCP is to be considered in the diagnostic work-up of patients with BPH.
The commonest s-MRCP finding in patients with BPH was chronic pancreatitis (65,7%), followed by SOD (31,7%) and acinar filling (9,5%). Despite everything, the pancreatic exocrine function was normal in 96,7% of patients.
To explain these alterations may be postulated...
Personal information and conflict of interest
C. Gullì; Rome/IT - nothing to disclose A. Marrazzo; Rome/IT - nothing to disclose G. Restaino; Campobasso/IT - nothing to disclose M. Missere; Campobasso (CB)/IT - nothing to disclose E. Cucci; Campobasso/IT - nothing to disclose G. Sallustio; Campobasso (CB)/IT - nothing to disclose
References
[1] Gullo L. Chronic nonpathological hyperamylasemia of pancreatic origin. Gastroenterology. 1996; 110(6):1905–1908.
[2] Warshaw AL, Lee KH. Macroamylasemia and other chronic nonspecific hyperamylasemias: chemical oddities or clinical entities? Am J Surg. 1978; 135:488–493.
[3] Mortele KJ, Wiesner W, Zou KH et al. Asymptomatic nonspecific serum hyperamylasemia and hyperlipasemia: spectrum of MRCP findings and clinical implications. Abdom Imaging 2004; 29:109–14.
[4] Donati F, Boraschi P, Gigoni R et al. Secretin-stimulated MR cholangiopancreatography in the evaluation of asymptomatic patients with nonspecific pancreatic hyperenzymemia. Eur J Radiol 2010;...