Keywords:
Performed at one institution, Diagnostic or prognostic study, Prospective, Tissue characterisation, Hyperplasia / Hypertrophy, Imaging sequences, Contrast agent-intravenous, MR, Cardiac
Authors:
A. Cassar Scalia, L. Ruoli, F. Fiocchi, G. Ligabue, P. Torricelli; Modena/IT
DOI:
10.26044/ecr2020/C-13455
Results
A Gauss curve distribution of T1 values obtained in healthy subjects was shown at statistical analysis, with similar distribution trend also considering two subgroups of age 18–65 years and >65 years. The average T1 value in healthy subjects was 1226±64 ms, which was adopted as local reference standard.
Secondly a comparison was made between values of native T1 and ECV obtained in healthy subjects and in patients with amyloidosis: the average native T1 value in this last group was 1386±72 ms and the average ECV value was 50,7±13 %, with statistically significant difference from healthy people values (T-test, p<0,0001 and p<0,0002 respectively) (Fig.3). ROC curves showed how both parameters have a high diagnostic accuracy: 97,8% for native T1 and 86,8% for ECV (Fig.4).
Finally the results of our small subgroup of four patients affected by ATTR amyloidosis proven by scintigraphy were compared with those ones of six patients with other forms of amyloidosis. In ATTR patients the mean native T1 value was 1430±44, while that of other patients was 1360±76; the mean ECV value in the first subgroup was 64,6±6,4 while in the second one was 42,4±7,1, with statistically significant difference (ANOVA test, p<0,0001) (Fig.5).