Learning objectives
1. Review the epidemiology, clinical presentations, diagnosis and treatment of sporotrichosis.
2. Describe the imaging features of musculoskeletal sporotrichosis.
3. How to perform a differential diagnosis of sporotrichosis and other conditions.
Background
1. INTRODUCTION
Sporotrichosis is a rare, chronic fungal infection caused by Sporothrix species found in soil, animal excreta, and vegetation, of worldwide distribution, most commonly found in tropical and temperate regions (Figure 1). The infection is acquired through traumatic inoculation or by inhalation of conidia. Another well-documented mode of transmission is zoonotic, mainly via cat scratches, and, less often, from armadillos or insect, rodent and dog bites.
The classical species S. schenckii is a cosmopolitan pathogen that exhibit moderate virulence in animal models and is...
Findings and procedure details
Routine imaging studies are usually not needed for the diagnosis of cutaneous sporotrichosis, but screening for bone lesions in patients either immunosuppressed or with exuberant skin lesions is important to determine treatment.
1. Radiographs
Osteopenia;
Osseous erosions;
Periarticular erosions indicating chronic synovitis;
Joint space narrowing;
Joint effusions;
Surrounding soft-tissue swelling;
Adjacent bone destruction.
2. Ultrasound
Joint effusion;
Hyperechoic synovial proliferation.
3. Computed Tomography
Similar findings to radiographs, with better visualization of joint effusion and osseous erosions;
Draining sinus tract to the skin may be identified....
Conclusion
Despite being rare, the osteoarticular form of sporotrichosis is considered the most common extracutaneous manifestation.
S. brasiliensis is highly virulent and shows a preponderance of cat-transmitted infection.
Culture remains the gold standard and most sensitive method of diagnosis.
The main imaging findings are soft-tissue swelling, osteoporosis, synovial hypertrophy, bone erosions and osteomyelitis.
Diagnostic delay is related to disease severity requiring longer treatment and may result in long-term sequelae or even death.
The differential diagnosis for osteoarticular sporotrichosis includes other atypical infections, rheumatoid arthritis, pigmented villonodular...
Personal information and conflict of interest
E. M. Lima; Rio De Janeiro, RIO DE JANEIRO/BR - nothing to disclose M. N. Chenu; Rio de Janeiro/BR - nothing to disclose V. T. Salzani; Rio de Janeiro, RIO DE JANEIRO/BR - nothing to disclose C. G. C. Chantong; Rio de Janeiro/BR - nothing to disclose A. L. Dutra; Rio de Janeiro/BR - nothing to disclose E. B. G. Dos Santos; RIO DE JANEIRO, RJ/BR - nothing to disclose R. V. de Oliveira; Rio de Janeiro/BR - nothing to disclose H. A. Affonso; Rio...
References
[1] Chakrabarti A, Bonifaz A, Gutierrez-Galhardo MC, Mochizuki T, Li S. Global epidemiology of sporotrichosis. Medial Mycology 2015; 53,3-14.
[2] Rodrigues AM, Hoog GS, Camargo ZP. Sporothrix Species Causing Outbreaks in Animals and Humans Driven by Animal-Animal Transmission. PLoS Pathogens 2016; 12(7): e1005638.
[3] Lopes-Bezerra LM, Mora-Montes HM, Zhang Y, et al. Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents. Medical Mycology 2018; 56,S126-S143.
[4] Lederer HT, Sullivan E, Crum-Cianflone NF. Sporotrichosis as an unusual...