Purpose
Diffuse lung diseases diagnosis is commonly challenging and requires collaboration among different experts, as well as the ability to interpret and communicate under conflicting information.In many cases it is not possible to identify the etiological factors. (1, 2)
Idiopathic pulmonary fibrosis is the most common entity and carries the worst prognosis. However, recent medications with proven effect in the disease progression have been approved, and have also been considered in other progressive fibrosing lung diseases. (3, 4)
Important guidelines were published recently, addressing diagnostic criteria...
Methods and materials
This is an observational, cross-sectional and unicentric study with retrospective data collection.
Patient population:44 patients with diffuse lung disease (65% women, from 22 to 79 years old, mean age 58,4) who underwent lung biopsy and chest HRCT at our institution between 2010 and 2018. Exclusion criteria: patients with inaccurate registration or unavailability of clinical or histological data; chest computed tomography performed at another institution or under an inadequate protocol; patients with final diagnoses not included in the study interest, such as infectious diseases.
Data analysis:Five...
Results
A summary of the results is avaiable in table 2.The most prevalent HRCT pattern was “most consistent with non-IPF diagnosis” (54.5% - 63.6%) (figure 2).There was moderate to high agreement in the classification among the four thoracic radiologists (k 0.61). Experts agreement for a binary score “typical UIP/probable UIP” or “indeterminate for UIP/most consistent with non-IPF diagnosis” was high (k 0.79). When the radiology resident was included in the analysis (total of five observers), the agreement in the diagnostic classification was moderate (k 0.59) and...
Conclusion
In this study, interobserver agreement for the current Fleischner Society HRCT criteria for UIP was moderate among observers with different levels of experience (k 0,59 – 0,61). There are many studies evaluating the diagnostic accuracy of HRCT in diffuse lung diseases. Intra and inter-observer diagnostic disagreements on HRCT have been reported, as well as disagreements among clinicians, radiologists, and pathologists, and low confidence in the diagnosis. (7-9) However, specific data on diagnostic classifications of IPF-PIU on HRCT are rare. A multicentric study published by Walsh...
Personal information and conflict of interest
S. S. Westphalen; Porto Alegre/BR - nothing to disclose F. Soares Torres; Toronto/CA - nothing to disclose T. S. Garcia; Porto Alegre/BR - nothing to disclose
References
Raghu G, Nyberg F, Morgan G. The epidemiology of interstitial lung disease and its association with lung cancer. Br J Cancer. 2004;91 Suppl 2:S3-10.
Gribbin J, Hubbard RB, Le Jeune I, Smith CJ, West J, Tata LJ. Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK. Thorax. 2006;61(11):980-5.
Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2071-82.
Flaherty KR, Wells AU, Cottin...