Learning objectives
Pictorial review of hematological diseases (i.e. lymphoma, plasmocytoma, multiple myeloma) and oncological pathologies (primary tumors and metastases) with PET-CT and musculoskeletal involvement as debut.
Role of PET-CT in the follow up of these diseases.
Background
The image obtained by the PET tomograph is based on capturing the emission of photons radiation resulting from the annihilation reaction of the positrons emitted by radionuclides, with the electrons of matter. The signal is captured and processed and a three-dimensional image is obtained that informs us of the distribution of the emitting radionuclide tagged tracer molecule, which is chosen to mark a specific function in the body on a biochemical level. Therefore PET provides molecular imaging of biological function.
The primary attribute of PET...
Findings and procedure details
We reviewed the PET-CT studies from the last 10 years in our institution with anatomopathological (confirmation) and regarding their musculoskeletal debut we divide them in SCC: spinal cord compression, bone lesion, soft tissue lesion or pathological fracture. [Fig 1]
SCC: spinal cord compression
SCC is a medical emergency that requires prompt diagnosis and treatment to avoid irreversible spinal cord injury. Imaging tests are essential to confirm the clinical suspicion and also, grading the severity of the disease and narrowing down the differential diagnosis. The most...
Conclusion
Multiple hematological and oncological diseases have a musculoskeletal debut. The PET / CT is a unique technique in the diagnosis and follow up of these diseases. Radiologists must be familiar with these imaging studies in order to better understand the management of musculoskeletal lesions.
Personal information and conflict of interest
P. García García:
Nothing to disclose
M. C. Iniesta González:
Nothing to disclose
V. Rodriguez Laval:
Nothing to disclose
V. Castillo:
Nothing to disclose
I. Hernández:
Nothing to disclose
M. J. Moreno Casado:
Nothing to disclose
N. Gómez Leon:
Nothing to disclose
References
The role of positron emission tomography in skeletal disease.Cook GJ, Fogelman I et al. Semin Nucl Med. 2001 January 31, (1), 50-61
Whole-Body Imaging of Multiple Myeloma: Diagnostic Criteria. Ormond Filho AG, Carneiro BC, Pastore D, Silva IP, Yamashita SR, Consolo FD, Hungria VTM, Sandes AF, Rizzatti EG, Nico MAC. Radiographics. 2019 Jul-Aug;39(4):1077-1097.
CT appearance of bone metastases detected with FDG PET as part of the same PET/CT examination. Nakamoto Y, Cohade C, Tatsumi M, Hammoud D, Wahl RL. Radiology. 2005 Nov;237(2):627-34
Detection of bone...