Comparison of 68Ga-PSMA-11 and 18F-PSMA-1007 PET/CT for the detection of local recurrence and lymph node metastases in biochemical recurrence of prostate cancer

Congress:

ECR 2022

Poster Number:

C-17749

Type:

Scientific Exhibit

Keywords:

Genital / Reproductive system male, Nuclear medicine, Oncology, PET-CT, Molecular imaging, Cancer, Metastases

Authors:

L. Saule, M. Radzina, M. Liepa, A. Lioznovs, L. Roznere, L. Zemniece, M. Kalnina, E. Mamis, E. Vjaters

DOI:

10.26044/ecr2022/C-17749

DOI-Link:

https://dx.doi.org/10.26044/ecr2022/C-17749

References

1 - Rowe SP, Macura KJ, Mena E, et al. PSMA-Based [(18)F]DCFPyL PET/CT Is Superior to Conventional Imaging for Lesion Detection in Patients with Metastatic Prostate Cancer. Mol Imaging Biol. 2016;18(3):411-419. doi:10.1007/s11307-016-0957-6

2-Radzina M, Tirane M, Roznere L, Zemniece L, Dronka L, Kalnina M, Mamis E, Biederer J, Lietuvietis V, Freimanis A, Vjaters E. Accuracy of 68Ga-PSMA-11 PET/CT and multiparametric MRI for the detection of local tumor and lymph node metastases in early biochemical recurrence of prostate cancer. Am J Nucl Med Mol Imaging. 2020 Apr 15;10(2):106-118. PMID: 32419979; PMCID: PMC7218697.

3- Paddubny K, Freitag MT, Kratochwil C, Koerber S, Radtke JP, Sakovich R, Kopka K, Giesel FL. Fluorine-18 Prostate-specific Membrane Antigen-1007 Positron Emission Tomography/Computed Tomography and Multiparametric Magnetic Resonance Imaging in Diagnostics of Local Recurrence in a Prostate Cancer Patient After Recent Radical Prostatectomy. Clin Genitourin Cancer. 2018 Apr;16(2):103-105. doi: 10.1016/j.clgc.2017.09.014.

4 - Saule L, Radzina M, Liepa M, Roznere L, Kalnina M, Lioznovs A, Mamis E, Mikelsone M, Biederer J, Vjaters E. Diagnostic scope of 18F-PSMA-1007 PET/CT: comparison with multiparametric MRI and bone scintigraphy for the assessment of early prostate cancer recurrence. Am J Nucl Med Mol Imaging. 2021 Oct 15;11(5):395-405. PMID: 34754610; PMCID: PMC8569331.

Fig 5: Table 1 - 68Ga-PSMA-11 PET/CT accuracy in recurrent prostate cancer

Fig 6: Table 2 - 18F-PSMA-1007 PET/CT accuracy in recurrent prostate cancer

Fig 7: Table 3 - A chi-square test of independence between both PSMA PET/CT methods

Fig 1: Figure 1 - 68Ga-PSMA- 11 PET/CT examination : accumulation in the left side of...

Fig 2: Figure 2 - 18F-PSMA-1007 PET/CT examination : A,B - focal 18F-PSMA-1007...

Fig 3: Figure 3 - 68Ga-PSMA- 11 PET/CT examination : 68Ga-PSMA- 11 uptake in right...

Fig 4: Figure 4 - 18F-PSMA-1007 PET/CT examination - A,B: pathological 18F-PSMA-1007...