Comparison of 68Ga-PSMA-11 and 18F-PSMA-1007 PET/CT for the detection of local recurrence and lymph node metastases in biochemical recurrence of prostate cancer

Congress:

ECR 2022

Poster Number:

C-17749

Type:

Scientific Exhibit

Keywords:

Genital / Reproductive system male, Nuclear medicine, Oncology, PET-CT, Molecular imaging, Cancer, Metastases

Authors:

L. Saule, M. Radzina, M. Liepa, A. Lioznovs, L. Roznere, L. Zemniece, M. Kalnina, E. Mamis, E. Vjaters

DOI:

10.26044/ecr2022/C-17749

DOI-Link:

https://dx.doi.org/10.26044/ecr2022/C-17749

Purpose

New radiopharmaceuticals ⁶⁸Ga-PSMA-11 and ¹⁸F-PSMA-1007 have substantially increased the diagnostic scope of radionuclide imaging for recurrent prostate cancer (PCa) and treatment strategy. Hybrid imaging with Positron emission tomography in combination with computer tomography (PET/CT) is a functional and anatomical non-invasive imaging modality used in the detection and staging of prostate cancer, in the evaluation of treatment efficacy and localization of recurrence [1]. Comparing both, ⁶⁸Ga-PSMA-11 ligand has a drawback in the assessment of small local recurrences, which is its excretion via the kidneys and high accumulation in the urinary bladder [2]. Low urinary background clearance of ¹⁸F-PSMA-1007 provides higher diagnostic value of PET/CT in evaluation of the prostate bed and pelvis in recurrent PCa patients [3,4]. The aim of this study was to determine the accuracy of both radiopharmaceuticals - ⁶⁸Ga-PSMA-11 and ¹⁸F-PSMA-1007 PET/CT for evaluation of local recurrence and regional lymph nodes.

Fig 5: Table 1 - 68Ga-PSMA-11 PET/CT accuracy in recurrent prostate cancer

Fig 6: Table 2 - 18F-PSMA-1007 PET/CT accuracy in recurrent prostate cancer

Fig 7: Table 3 - A chi-square test of independence between both PSMA PET/CT methods

Fig 1: Figure 1 - 68Ga-PSMA- 11 PET/CT examination : accumulation in the left side of...

Fig 2: Figure 2 - 18F-PSMA-1007 PET/CT examination : A,B - focal 18F-PSMA-1007...

Fig 3: Figure 3 - 68Ga-PSMA- 11 PET/CT examination : 68Ga-PSMA- 11 uptake in right...

Fig 4: Figure 4 - 18F-PSMA-1007 PET/CT examination - A,B: pathological 18F-PSMA-1007...