Our study demonstrates the importance of the morphological CT features of GISTs, which proved their significance in the risk stratification of these tumors. To our knowledge, there are several studies that investigated CT features in correlation to risk stratification of gastric GIST (1-4). Zhou et al. showed similar results to ours that independent predictive factors for the risk stratification of GISTs were tumor size, EFDV and mixed growth pattern (1). Tateishi et al. reported that tumor diameter larger than 11 cm, the presence of metastases...

Sixty-two patients with histologically proven GIST who underwent CT perfusion and MR-DWI using multiple b-values were prospectively included. Morphological CT characteristics were comparatively analyzed in the high-risk (HR) and low-risk (LR) GIST groups. CT imaging features were analyzed as follows: maximal diameter in the axial slice and tumor structure, which was classified into cystic and solid/necrotic. The shape was depicted as regular or irregular. Tumor localization considered the body of the stomach, antrum or pyloric region. Mucosa was observed in two ways: intact/continuous or disrupted....

Univariate analysis revealed that greater tumor diameter (p< 0.001), cystic structure (p< 0.001), irregular margins (p= 0.007), irregular shape (p< 0.001), disrupted mucosa (p< 0.001) and visible EFDV (p < 0.001), were significant predictors of HR GIST (Table1). Multivariate analysis extracted the irregular shape (p= 0.006) and visible EFDV (p = 0.017) as the independent predictive CT features of HR GIST. The ROC analysis revealed that multivariate linear regression model, which included the shape of the tumor together with the EFVD, achieved an AUC of...

In summary, our research resulted in a regression model where the irregular tumor shape and presence of EFDV were the most significant and independent predictors for the high metastatic potential of gastric GISTs. This result shows that morphological characteristics of the tumor detected by conventional CT examination still hold the greatest value in the preoperative risk stratification of gastric GIST.

M. Mitrovic: Nothing to disclose A. Djuric-Stefanovic: Nothing to disclose J. Kovac: Nothing to disclose A. Jankovic: Nothing to disclose D. Šaponjski: Nothing to disclose L. Lazic: Nothing to disclose S. Milosevic: Nothing to disclose K. Ebrahimi: Nothing to disclose M. Micev: Nothing to disclose

Zhou, C.; Duan, X.; Zhang, X.; Hu, H.; Wang, D.; Shen, J. Predictive features of CT for risk stratifications in patients with primary gastrointestinal stromal tumour.Eur. Radiol.2016,26, 3086–3093. [Google Scholar] [CrossRef] Tateishi, U.; Hasegawa, T.; Satake, M.; Moriyama, N. Gastrointestinal stromal tumor. Correlation of computed tomography findings with tumor grade and mortality.J. Comput. Assist. Tomogr.2003,27, 792–798. [Google Scholar] [CrossRef] Kim, H.C.; Lee, J.M.; Kim, K.W.; Park, S.H.; Kim, S.H.; Lee, J.Y.; Han, J.K.; Choi, B.I. Gastrointestinal stromal tumors of the stomach: CT findings and prediction...