Stroke is the leading cause of death and disability in adults in China, with the prevalence of stroke risk factors becoming increasingly evident due to the acceleration of population aging and urbanization. Among these risk factors, the incidence of ischemic stroke is on the rise. According to data from 2019 in China, the number of cases of ischemic stroke admitted to primary hospitals accounts for more than half of the total cases of stroke, highlighting the importance of prevention and control efforts. However, there are...

PatientsThe clinical data and head CT plain images from 128 ischemic stroke patients (stroke group) and 93 normal controls (control group) admitted to Chongqing Western Hospital from January 2022 to December 2022 were enrolled. The mean age of the stroke group was (70.55±13.04) years, and the sex ratio of male to female was 70:58. In control group, the mean age was (66.26±12.54) years old, the sex ratio was 56:37. Inclusion criteria for ischemic stroke: (1) onset within 24 h; (2) Complete clinical and laboratory data;...

Utilizing LASSO regression, 14 features were ultimately selected shown in Figure 2, including 1 first-order feature, 4 GLSZM features, 1 GLRLM feature, and 8 GLCM features . [Fig 2]The ROC curves for the radiomics model in both the training and validation sets demonstrated an AUC of 0.91 for the cerebral hemisphere with infarct lesions and 0.87 for the normal cerebral hemisphere.[Fig 3]The simulated NIHSS model of multivariate linear model fitting are as follows: PredictNIHSS=-1.893116723401267+ 0.45575591*gender '+0.01179382*' age '+0.58878099*' Hypertension '+0.14576505*' Diabetes' -0.15405688* 'Smoking' +0.07508585* 'TIA'...

The score of the model based on the integration of clinical and radiomics features is highly consistent with the NIHSS score of senior residents, which can effectively improve the diagnostic accuracy of ischemic stroke in primary care doctors.Limitations(1) Among the cases included in this study, the maximum NIHSS score of experts was 23, thus the ability of the fitted model to evaluate patients with NIHSS scores higher than 23 points needs to be further investigated. (2) This study is a single-center study, and the generalizability...

Z. Li: Nothing to disclose S. Meng: Nothing to disclose

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