Type:
Poster Presentation
Keywords:
Cardiac, Computer applications, MR, Image manipulation / Reconstruction, Diagnostic procedure, Computer Applications-3D, Segmentation, Inflammation
Authors:
O. Aparina, O. Stukalova, D. Parkhomenko; Moscow/RU
Purpose
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and affects about 1-2% of general population.
It increases mortality and causes life quality decrease.
The myocardium of right and left atria (RA,
LA) is a substrate for atrial fibrillation.
Atrial fibrillation is accompanied by atrial electrical and structural remodeling .
The morphologic studies showed that atrial structural remodeling is expressed as atrial enlargement and walls thinning on the background of inflammation and fibrosis sites in myocardium.
And these changes may be found in both in AF patients with cardiovascular disease and patients with lone AF.
Prospective clinical studies give the evidence that atrial structural remodeling is an important factor for the disease progression.
It also contributes to fail of rhythm control strategy. The presence of atrial structural remodeling in patients with AF leads to worth results of the pulmonary veins ablation procedure,
cardioversion and AF recurrence.
Further research of atrial structural remodeling is need to provide the information how it can influence on clinical course of disease and results of different therapeutic approach.
Also is important to know how traditional and new treatment strategies can influence on atrial fibrosis.
Late gadolinium enhancement MRI (LGE MRI) is a well-established method to evaluate scar and diffuse fibrosis in left ventricle. Recent studies showed LGE MRI is a feasible noninvasive tool for atrial fibrosis and scar detection.
The aim of the study is:
1) to review the technical aspects and limitations of performing images of LA and RA
2) to describe different algorithms for atrial postablation scar and preablation fibrosis detection
3) to evaluate the clinical reasons to request LGE MRI of atria in order to assess the atrial scar and fibrosis in patients with AF