Keywords:
Hyperplasia / Hypertrophy, Statistics, Comparative studies, MR, Cardiac
Authors:
N. Lama, V. P. Patris, G. Velonakis, M. Mademli, E. Karavasilis, M. Argiriou, N. L. Kelekis; Athens/GR
Results
We retrieved and analyzed 47 different studies (fig.6) and 12 different review papers (fig.1). Since 2006 over 3860 patients with of aortic valve stenosis have been enrolled and evaluated, as well as 500 controls. Nowadays huge trials as EVoLVeD (Early Valve Replacement Guided by Biomarkers of Left Ventricular Decompensation in Asymptomatic Patients with Severe Aortic Stenosis (NTC003094143) are investigating new biomarkers to lead the forgoing strategic evaluation over targeting most beneficiary therapeutic patients’ approach.
Aortic valve stenosis is a disease with a complex phenotype, and its assessment is challenging as various stages provoke different expressions often discordant with ultrasonographic results. All parameters were evaluated through subgroup analysis, looking for potential relation between them.
Most of the studies were performed dividing patients and healthy control groups.
Since the 1st study on 2006 (18) there were another 30 studies evaluating LGE (fig.9), and 16 studies evaluating another parameter. Since 2012 there were a strong trend over Mapping techniques (fig.12). Except T1 native on mapping, there were also studies evaluating ECV, iECV and T2 mapping (fig.13). And except LGE, and Mapping there were also studies appraising myocardial hypertrophy and STRAIN. Most of the patients, in the majority of the studies, were suffering of severe AS and were listed for aortic valve replacement (AVR). 18 of the 47 studies were biopsy proven. Evaluation post-surgery, in order to be assessed the remodeling of the myocardium, was performed in 9 studies. Most of the studies were performed with the use of a 1,5T MRI scanner, 10 of the studies with the use of a 3T MRI scanner and 4 of them had used both type of scanners (fig.14).