Keywords:
Cancer, Observer performance, MR-Functional imaging, MR, Oncology, Musculoskeletal bone
Authors:
S. Berardo, L. SUKHOVEI , A. Trisoglio, E. Soligo, A. Stecco, A. Carriero; Novara/IT
DOI:
10.1594/essr2018/P-0003
Methods and Materials
Study group includes 23 patients (18M/5W; mean age 66y; range 39-82y) with diagnosis of MM (15 asymptomatic MM,
8 symptomatic MM) who had not yet received any treatment and had not any focal lesion in examined segments.
Control group includes 15 healthy volunteers (9M/6W; mean age 64y; range 51-72y).
Smokers,
patients with cardiac,
haematological and pulmonary pathology and BMI > 25 were excluded.
MR examinations were conducted on a 1.5T scanner.
We performed DWIBS with 3 b values (50-400-800 mm2/s) and coronal T1 SE sequences with chemical shift selective technique,
co-registering in phase (fat+water),
out phase (water-fat) and fat only.
Signal intensity was calculated placing the regions of interest (ROIs) within bone marrow of the 3 vertebras without focal lesions.
ADC was calculated placing a ROI in the same vertebras.
All parameters described were compared with bone marrow plasma cell percentage obtained from bone marrow biopsy.
Loss of signal on OP compared with IP (each one expressed as Signal Intensity Ratio,
normalised with muscle) is calculated as a quantitative measure rSIR (OP/IP).
We adopted the following statistical tests: Mann-Whitney comparison,
Pearson’s correlation tests and ROC analysis.