Usefulness of quantitative MRI with chemical shift imaging (Dixon) in detecting diffuse bone marrow infiltration in patients with multiple myeloma without focal lesion

Congress:

ESSR 2018

Poster Number:

P-0003

Type:

Scientific Poster

Keywords:

Cancer, Observer performance, MR-Functional imaging, MR, Oncology, Musculoskeletal bone

Authors:

S. Berardo, L. SUKHOVEI , A. Trisoglio, E. Soligo, A. Stecco, A. Carriero; Novara/IT

DOI:

10.1594/essr2018/P-0003

DOI-Link:

https://dx.doi.org/10.1594/essr2018/P-0003

Table 1: ROC curve for three groups of patients: the AUC of SIRr is 0,669 with IC of...

Fig. 1: 67-years old man with symptomatic myeloma without focal lesions. Region of...

Purpose

Diffusion-weighted imaging (DWI) images in association with ADC maps and chemical shift (CS) in myeloma are introduced as problem-solving sequences to evaluate bone marrow abnormalities. In our study we tried to understand the utility of Dixon quantitative CS to identify bone marrow reconversion which can be a predictive factor of progression from asymptomatic to symptomatic myeloma, before the appearance of focal lesions.

Methods and Materials

Study group includes 23 patients (18M/5W; mean age 66y; range 39-82y) with diagnosis of MM (15 asymptomatic MM, 8 symptomatic MM) who had not yet received any treatment and had not any focal lesion in examined segments. Control group includes 15 healthy volunteers (9M/6W; mean age 64y; range 51-72y). Smokers, patients with cardiac, haematological and pulmonary pathology and BMI > 25 were excluded. MR examinations were conducted on a 1.5T scanner. We performed DWIBS with 3 b values (50-400-800 mm2/s) and coronal T1 SE sequences...

Results

Mean ADC values (+/- DS, x 10-3 mm2/s): 0,513 +/- 0,097 (range 0,941-0,312) in patients with asymptomatic MM; 0,589 +/- 0,098 in patients with asymptomatic MM and 0,401+/- 0,055 in healthy controls. The mean relative intensity ratio (rSIR) in patients with MM is 2,9 +/- 1,46 (mean±ds), with a range of 1,48-8,15. The mean relative signal intensity ratio in healthy patiens is 3,5 +/- 1,44 (range 1,69-4,78). We applyed the Mann-Whitney test for the comparison of mean values of the SIRr: there is no statistically...

Conclusion

rSIR using Dixon Quantitative CScan’t be used for evaluation of the degree of infiltration pattern in patient with different types of MM.

References

1. Rajkumar SV, Larson D, Kyle RA, Diagnosis of smoldering multiple myeloma. N Engl J Med; 2011; 365:474–475. 2. Filippo Del Grande, Sahar J Farahani, John A Carrino, and Avneesh Chhabra. Bone marrow lesions: A systematic diagnostic approac. Indian J Radiol Imaging; 2014; 24(3): 279–287. 3. Padhani AR, Koh DM, Collins DJ. Whole-body diffusion-weighted MR imaging in cancer: Current status and research directions. Radiology; 2011; 261:700–18. 4. Takasu M, Tani C, Sakoda Y, Ishikawa M, Tanitame K, et al. Iterative decomposition of water and fat...