Keywords:
Musculoskeletal soft tissue, Oncology, MR, MR-Diffusion/Perfusion, Diagnostic procedure, Tissue characterisation, Cancer
Authors:
E. Aktas, M. Arikan, F. ARDIC, B. S. Sahin, J. karakaya, G. Togral, B. K. Arıbaş; Ankara/TR
DOI:
10.1594/essr2018/P-0005
Results
Recurrent tumors were identified in 15 of the 42 patients included in the study.
Out of these patients 6 (40%) were female and 9 (60%) were male.
Out of the 27 patients classified as postoperative tissue changes,
14 (51,8%) were women and 12 (48,1%) were male.
There was no statistical difference in respect to gender between the two groups (p=0.183).
The mean age of patients with recurrent tumors identified was 51,6±19,5 and the mean age of patients with postoperative tissue changes was 51,07± 1,37.
No significant difference was identified between the groups in respect to age (p=0.909) (Table 1).
No statistical difference was present between the tumor types in respect to the ADC calculations at all b levels.
There was no meaningful correlation between the histopathological grade and ADC values.
22 of the tumors were located in the thigh.
Out of the other tumors,
5 were in the cruris,
3 in the popliteal fossa,
3 in the forearm,
2 neighboring the knee,
2 in the shoulder,
2 in the arm,
1 in the antecubital fossa,
1 neighboring the hip and 1 in the elbow respectively.
Among the lesions considered as posttreatment tissue changes 4 were fluid collections; 3 were postoperative hematomas.
The other 18 lesions were T1 hypointense and T2 hyperintense and enhanced minimally following IV contrast administration.
When the group of recurrent tumor patients was compared to the postoperative changes group,
the ADC calculations were statistically significantly lower at all b levels (p<0.001) (Table 1).
The ADC values of recurrent tumors,
areas of postoperative tissue change and adjacent healthy muscular tissues measured at different b values are summarized in Table 1.
The sensitivity of b 50 values lower than 3,01 x103 mm²/sec in showing recurrent tumors was 100% and the specificity was 77,78%.
The sensitivity of b 400 values lower than 2.1 x103 mm²/sec in showing recurrent tumors was 80% and the specificity was 96,3%.
The sensitivity of b 800 values lower than 2.26 x103 mm²/sec in showing recurrent tumors was 100% and the specificity was 88,89%.
The sensitivity of b 1000 values lower than 2.05 x103 mm²/sec in showing recurrent tumors was 93.3% and the specificity was 92,5% (Table 2). No significanrt difference was identified among the b 50,400,800 and 1000 values in differentiating tumor recurrence from the postoperative chamges.
(p=0,91 for b 50 and 400,
p=0,28 for b50-800,
p=0,79 for b50-1000,
p=0.12 for b 400-800,
p=0,80 for b 400-1000,
p=0,31 for b 800-1000,
significan after Bonferroni’s correction p< 0,00833)