Imaging-related radiation dose in cystic fibrosis lung transplant recipients: is there a relation with de novo malignancy?

Congress:

EuroSafe Imaging 2018

Poster Number:

ESI-0011

Type:

EuroSafe Imaging

Keywords:

PET-CT, CT, Conventional radiography, Radioprotection / Radiation dose, Lung, Action 10 - EuroSafe Imaging Stars, Action 6 - Clinical audit tool for imaging, Action 8 - EuroSafe Imaging Stars network and data collection, Action 2 - Clinical audit, Radiation safety, Transplantation

Authors:

I. Fitton, M.-P. Revel, P.-R. BURGEL, A.-C. HERNIGOU, V. Boussaud, R. GUILLEMAIN, F. Le Pimpec-Barthes, G. Frija, G. CHASSAGNON

DOI:

10.1594/esi2018/ESI-0011

DOI-Link:

https://dx.doi.org/10.1594/esi2018/ESI-0011

Fig. 1: Flow chart

Fig. 2: Mean cumulative effective dose per patient per 6-month periods during follow-up...

Table 1: Ionizing radiation procedures after lung transplantation

Table 2: De novo malignancies

Background/introduction

Lung transplantation (LTX) recipients are exposed to repeated ionizing radiation procedures during follow-up, potentially increasing the malignancy risk [1-4]. The purpose of this study was to evaluate the cumulative post-transplantation radiation dose in cystic fibrosis (CF) LTX recipients and to compare doses of patients with and without de novo malignancy.

Description of activity and work performed

Methods and Materials: Study design This retrospective cohort study was approved by the Institutional Review Board of the French learned society for respiratory medicine -Société de Pneumologie de Langue Française, which waived the need for patients’ consent (reference number CEPRO 2017-030). Patient’s characteristics All CF patients who had undergone LTX, alone or in combination with other organ transplantation at Hôpital Européen Georges Pompidou, between January 2001 and December 2006 were retrospectively included if they had at least 3-year survival (Fig.1). Patient’s charts were analyzed for...

Conclusion and recommendations

In conclusion, CED happened to exceed the limit of 100mSv over 5 years in nearly 40% of our CF patients, mainly because of chest CT. Even though most cancers were attributable to immunosuppression, with no significant association found between radiation dose and de novo malignancy, continuous attention should be paid to limit radiation exposure after lung transplantation.

Personal/organisational information

Corresponding author: Pr Marie-Pierre REVEL Address: Service de Radiologie A, groupe Hospitalier Cochin Broca Hôtel-Dieu, AP-HP, 27 rue du faubourg Saint-Jacques 75014 PARIS FRANCE email: [email protected]

References

[1] Donadieu J, Roudier C, Saguintaah M, Maccia C, Chiron R. Estimation of the radiation dose from thoracic CT scans in a cystic fibrosis population. Chest 2007;132(4):1233–1238. [2] Preston DL, Shimizu Y, Pierce DA, Suyama A, Mabuchi K. Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997. Radiat Res 2003;160(4):381–407. [3] De Bruin ML, Sparidans J, Veer MB van’t, et al. Breast cancer risk in female survivors of Hodgkin’s lymphoma: lower risk after smaller radiation volumes. J Clin...