Congress:
EuroSafe Imaging 2019
Keywords:
Action 7 - Radiation protection of children, Action 4 - Dose management systems, Action 2 - Clinical diagnostic reference levels (DRLs), Thorax, Lung, Radioprotection / Radiation dose, CT, CT-High Resolution, Comparative studies, Dosimetry, Radiation effects, Outcomes, Genetic defects
Authors:
K. P. Sheahan, D. Glynn, F. boland, O. O’Connor, A. Brady, M. A. Maher
DOI:
10.26044/esi2019/ESI-0027
Description of activity and work performed
Methods
A systematic search of PubMed,
the Cochrane library,
Embase,
and Scopus was performed.
Primary outcome was the reported reduced effective dose and secondary outcome was image quality.
Articles concerning dose reduction chest CT compared to standard dose chest CT in CF patients were included.
Two authors screened and selected articles.
All studies were subjected to an assessment of quality (QUADAS-2 Tool).
Results
A pre-determined search strategy yielded 134 articles.
Duplicates were removed, screening of titles/abstracts and full text review of 32 articles was performed. 12 studies were included.
The total number of patients in all included studies was 364 (median 21,
mean 33,
range 1-124).
Age range was 1 month – 58 years.
Outcome 1 - Radiation dose
The median reported reference dose of unenhanced standard dose chest CT was 1.36mSv (range 0.51 – 10.7).
This decreased to a mean at reduced dose levels of 0.28mSv.
The median percentage dose reduction achieved with dose reduction techniques was 78% (mean 76%,
range 49-95%).
Outcome 2 - Image quality
Reduced dose levels,
compared with local reference dose levels,
led to improved image quality in 25% (three studies,
(5,
7-8)), similar image quality in 50% (six studies,
(4,
6,
9-12)), or degraded image quality based on subjective assessment in 25% (three studies,
(1,
13-14)). At reduced dose levels,
objective image quality improved in two studies (5,
6) and was similar to standard dose chest CT in another study (4).