Purpose
Initial assessing the role of Whole-Body Diffusion-Weighted Magnetic Resonance Imaging (WBDW- MRI) in comparison with PET/CT for detection of metastases.
Diffusion MRI is a specific Magnetic Resonance Imaging (MRI) modality that produces in vivo images of biological tissues weighted with the local microstructural characteristics of water diffusion.
Whole-Body Diffusion-Weighted Magnetic Resonance Imaging (WBDW- MRI) has the potential to help detect primary tumors and metastasis.
Differentiating benign from malignant lesions,
and determining the presence of disease recurrence.
DW- MR imaging enables qualitative and quantitative assessment of...
Methods and Materials
We retrospectively evaluated the cases of 43 patients (19 women,
24 men; age range,
42–65 years),
diagnosed primary cancer.
All the patients executed whole-body diffusion weighted MRI on the Siemens Avanto 1,5T MRI,
syngo TimCT,
Gradient 45 mTm SR 200 T/m/sec,
16-channel body- array coils and the results were compared with PEP/CT whole-body scanning (Biograph true D w/true V 64 slice,
Siemens) at the same time. DW sequence was performed in the Axial plane (4000/78; matrix,
192 x 192; field of view,
384 x 384...
Results
43 cases were executed whole-body MRI and PET/CT:
40 of 43 patients had confirmed metastasis.
1 case: showed additional small vertebral body metastasis that were not seen on PET/CT.
2 case: whole-body MRI showed one additional node in liver (metastasis) that was not seen on PEP/CT.
3 case Whole-body MRI showed one intra-abdominal lymph node (benign lymph node) that was not seen on PEP/CT.
1 case PET/CT showed one pelvic peritoneal focal had increased metabolic activity,
that was not seen on MRI.
All the cases...
Conclusion
Whole-body diffusion weighted MR imaging can be used for detection of metastases with high sensitivity.
It can replace PET / CT in screening for cancer metastases in the future.
References
1 A.
L.
Baert,
Leuven,
M.
F.
Reiser,
München,
H.
Hricak,
New York,
M.
Knauth,
Göttingen-MD; Diff usion-WeighteDiff usion-Weighted MR Imaging- Applications in the Body; Medical radiology
2 Bachir Taouli and Dow-Mu Koh; Diffusion-weighted MR Imaging of the Liver; Radiology January 2010 254:47-66.
3 Yoshiharu Ohno,
Hisanobu Koyama,
Yumiko Onishi,
Daisuke Takenaka,
Munenobu Nogami,
Takeshi Yoshikawa,
Sumiaki Matsumoto,
Yoshikazu Kotani,
and Kazuro Sugimura-MD ;Non–Small Cell Lung Cancer: Whole-Body MR Examination for M-Stage Assessment—Utility for Whole-Body Diffusion-weighted Imaging Compared with Integrated FDG PET/CT; Radiology August 2008...