Acinar cell cystadenoma (ACC) is an uncommon entity with unknown physiopathology described for the first time in 2002 (1-3).
Its diagnosis is based on pathological criteria: cystic lesion with epithelial lining of typical acinar cells without atypia (fig 1-2). 15 cases (8 of them multilocular) had been reported in litterature (1-7) but fully described pattern correlated with pathology was not reported.
Most of the time,
patients presented abdominal pain and preoperative diagnosis was branch...
Methods and Materials
A monocentric retrospective study was conducted including all patients (five) operated with confirmed pathological diagnosis of ACC with pre-operative imaging (CT and/or MRI) from 1996 to 2012.
Twenty successive patients with resected BD-IPMN without malignant transformation and with pre-operative MRI were also included in a “control group”.
The study was approved by our local institutional review board and patient consent was waived. Cases Five patients (four women and one man),
26 to 59...
Clinical and biological findings Clinical and biological findings of patients with ACC and BD-IPMN are described in table 1 : Patient ACC n=5 BD-IPMN n=20 p value Clinical features Sex (Female) 4 (80%) 12 (60%) 0,4 Age (years) 38,8 (8.01) 57,9 (13,30) 0.0059 Personal past history 1 Rheumatoid arthritis 1 duodenal adenocarcinoma - 1 breast cancer Familial history 1 Pancreatic adenocarcinoma 1 pulmonar carcinoma 1 diabetes 1 pancreatic adenocarcinoma - Diabetes 1 (20%) 0 0,04 Exocrine...
Our study described for the first time imaging criteria of acinar cell cystadenoma. Based on radio-pathological correlation,
we determined 4 morphological criteria which allowed us to differentiate ACC from its main differential diagnosis,
ACC appeared as a radiological entity,
made of numerous,
often calcified “close peripheral small cysts“,
without communication with the main pancreatic duct. Unlike IPMN,
ACC seems to haveno malignant potential.
their early recognition may lead...
Unilocular acinar cell cystadenoma of the pancreas an unusual acinar cell tumor.
Am J Clin Pathol.
2002 Aug;118(2):211-4. 2.
Acinar cystadenoma of the pancreas: a previously undescribed tumor.
Ann Diagn Pathol.
2002 Apr;6(2):113-5. 3.
Acinar cell cystadenoma of the pancreas: a new entity? Am J Surg Pathol.