Keywords:
Osteoporosis, Calcifications / Calculi, Instrumentation, CT, Absorptiometry / Bone densitometry, Musculoskeletal bone, Cardiovascular system
Authors:
A. Kokov, V. L. Masenko, S. E. Semenov, O. Barbarash; Kemerovo/RU
Purpose
Non-fracture osteopenia reflects the decline in bone mineral density without clinical manifestations characteristic of osteoporosis and of greatest interest for timely early prevention of osteoporosis and its complications.
The relationship processes and ectopic bone formation of arterial calcification is shown in the results of many studies. In calcified plaques was detected ectopic bone,
and in the walls of arteries and marked cells like osteoblasts and osteoklasts [1].
Numerous cellular and molecular components such as collagen type I,
osteonectin,
osteopontin,
osteoprogerin,
oxidized lipids,
regulate processes such as bone and vascular ectopic mineralization,
which may explain the relationship atherosclerotic calcification and osteoporosis regardless of age [2].
It should be noted mutual negative influence atherosclerosis and osteoporosis.
It proved a significant increase in calcium deposits in the coronary arteries with a decrease in bone density and an increased risk of heart attack [3].
It has also been detected in patients with severe calcification of the vascular walls frequently have low bone density,
and that a significant bone loss in these individuals correlates with a more rapid progression of calcification of the abdominal aorta,
whereas the lower MIC values correlate well with non-calcified plaques [4].
We have previously shown that male patients with decreased BMD develops more severe coronary atherosclerosis [5].
Aim of this study was to determine probability of the presence of osteopenic syndrome in patients with multifocal atherosclerosis based on the multislice computed tomography (MSCT) evaluation of vascular calcification.