Authors:
N. A. Kostenikov, L. A. Tyutin, N. P. Fadeev, V. E. Savello; St. Petersburg/RU
DOI:
10.1594/ECR03/C-0801
Methods and Materials
Method 2-D-PET scans (Ecat Exact 47) with attenuation correction were performed in 26 patients in postoperative period before and after radiation and polychemotherapy to exclude the BT recurrent growth and estimate their treatment efficiency. 30-min dynamic scanning was carried out immediately after intravenous administration of 250-350 MBq [11C]-Butyrate twice: in fasting patients and 1 h after 50g glucose orally. 20-min [18F]-FDG-PET static scanning was performed 30 min post injection of 185MBq [18F]-FDG. The T/NT ratio for both radiopharmaceuticals was evaluated, as well as the uptake and washout of fatty acid tracer in tumor as a curve. The diagnosis was verified histologically. The MRI or CT was performed in all patiens before and after the treatment. 17 patients out of 26 showed malignant tumors: 6 cases - anaplastic astrocytomas, 7 - glioblastomas, 4 meningosarcomas. In 9 patients the brain benign tumors were revealed: in 4 cases - benign meningiomas, in 3 oligodendroastrocytomas, in 2 - benign astrocytomas. The reccurent growth of malignant tumors was observed in 16 cases, benign tumors in 3 cases.