Purpose
To intra-individually compare gadobenate dimeglumine-enhanced MRI with gadopentetate dimeglumine-enhanced MRI,
mammography and ultrasound using a prospective,
multi-center double-blinded,
randomized protocol.
Methods and Materials
One hundred thirty-five women (52.25±12.61 years) with BIRADS 3/4 findings on mammography and/or ultrasound underwent two identical breast MRI exams in randomized order,
one with gadobenate dimeglumine and the other with gadopentetate dimeglumine each at a dose of 0.1 mmol/kg BW.
Of these patients,
88 underwent mammography and ultrasound,
21 only mammography and 26 only ultrasound.
MRI was performed at 1.5T using T2w and 3D spoiled T1w GRE sequences with a temporal resolution of ≤2 min.
Images were evaluated independently by three,
unaffiliated,
blinded radiologists...
Results
122 malignant lesions were confirmed at histology in 109 patients undergoing MRI and mammography while 123 were confirmed in 114 patients undergoing MRI and ultrasound.
All three readers noted significantly superior cancer nodule detection on gadobenate dimeglumine-enhanced MRI compared to gadopentetate dimeglumine-enhanced MRI (115-117 [94-96%] vs.
99-104 [81-85%] lesions detected; p<0.001).
Likewise,
all three readers noted significantly superior cancer nodule detection for gadobenate dimeglumine-enhanced MRI versus mammography (115-117 [94-96%] vs.
95 [78%] lesions detected; p<0.001) and ultrasound (112-116 [91-94%] vs.
89 [72%] lesions detected; p<0.001)....
Conclusion
Breast cancer detection is significantly better on MRI enhanced with 0.1 mmol/kg BW gadobenate dimeglumine compared with mammography,
ultrasound and MRI enhanced with 0.1 mmol/kg BW gadopentetate dimeglumine.
The improved detection of cancer nodules can be ascribed to the higher R1 relaxivity of gadobenate dimeglumine which enables improved lesion visualization and better depiction of malignant morphology.
References
Martincich L.
Faivre-Pierret M,
Zechmann CM,
et al.
Multicenter,
double-blind,
randomized,
intraindividual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine for MR imaging of the breast (DETECT).
Radiology.2011 EPUB Dec 16.
Pediconi F,
Padula S,
Dominelli V,
Luciani M,
Telesca M,
Casali V,
Kirchin MA,
Passariello R,
Catalano C.
Role of Breast MR Imaging for Predicting Malignancy of Histologically Borderline Lesions Diagnosed at Core Needle Biopsy: Prospective Evaluation.
Radiology.
2010; 257:653-661.
Carbonaro LA,
Verardi N,
Di Leo G,
Sardanelli F.
Handling a high relaxivity contrast...
Personal Information
Professor Fiona J.
Gilbert
University of Aberdeen
Aberdeen,
Scotland UK
[email protected]