The male:female ratio was 3.2:1,
with a mean age of 53 years (R: 32-77).
Patients were followed up until transplantation.
The mean follow-up was 80 days (R: 8-369).
The average creatinine level 15 days before,
immediately before,
2 days after and 15 days after the angioCT scan were 4.43 (R:1.76-6,31),
4.6 (R: 2.07-6.64),
4.6 (R: 2.36-6.8) and 4.9 (R: 2.1-7.5),
respectively.
There were not significant differences between the levels of creatinine immediately before the CT and 2 days after the CT (0.300) (graph 1).
Fig. 3: Graph 1. Differences between creatinine levels immediately before the test and 48 hrs after the angio-CT scan. Statistical analysis for related samples (Wilcoxon) showed no significant differences.
Only two (9.5%) patients presented with an increase in creatinine levels > 0.5mg/dl 2 days after the angio-CT.
However,
no worsening in renal function was observed in these patients.
In both cases,
a significant decrease in creatinine levels occurred after 15 days.
Table 2 shows variations in the creatinine levels in these patients.
Fig. 4: Table 2 shows the changes in creatinine levels in the two patients who fulfilled the diagnostic criteria for CIN
Although there was a significant increase in average creatinine levels between the measurement done immediately before and 14 days after the angio-CT (0.007),
this difference was not significant if we compare it with the increase observed between creatinine levels measured 15 days before and immediately before the angio-CT (0.6).
The increase observed after 15 days could be therefore attributed to the progression of disease itself.
There is,
however,
some degree of bias due to the small sample size.
Graph 2 shows the results of the statistical analysis.
Fig. 5: Graph 2. Differences between creatinine levels 14 days before, immediately before and 14 days after the angio-CT. Statistical analysis for related samples (Wilcoxon) showed no significant differences.
Only one patient started dialysis (37 days after the angio-CT) due to the impossibility of performing the living-donor transplantation.
The patient did not develop CIN,
showing an increase of 0.3 mg/dl (from 4.9 to 5.2 mg/dl) in his creatinine levels in the first 48 hrs.
Nineteen patients were transplanted during follow-up.
The mean time between angio-CT and kidney transplantation was 49 days.