Keywords:
Extremities, Musculoskeletal bone, Paediatric, Ultrasound, Ultrasound-Colour Doppler, Ultrasound-Spectral Doppler, Statistics, Diagnostic procedure, Arterial access, Haemodynamics / Flow dynamics, Cancer, Image registration
Authors:
I. Begun; Minsk Region/BY
DOI:
10.1594/ecr2013/C-2663
Methods and Materials
We analyzed data of integrated ultrasound investigation in 49 children and adolescents aged 7-17 years with prospectively confirmed diagnosis of osteogenic sarcoma (28) and Ewing's sarcoma (21).
In all cases process was localized in the tubular bones of the lower extremities. Patients with SE and OS received chemotherapy according to protocols EURO-EWING-99 and COSS-96,
EURAMOS respectively.
In comparison group were 42 children of similar age with benign tumors and tumor-like conditions (osteoid osteoma,
cyst,
fibrous dysplasia,
osteochondroma,
calcified hematoma,
venous dysplasia).
For all were estimated: cardiac output (CO),
volume of blood flow in common femoral artery (Q ml/min),
indicies - resistance and pulsation (RI-resistive index,
PI-pulsatility index),
as well as size of their percentage deviations for the affected limb compared with the contralateral (%Q,
%RI,
%PI).
When evaluating the diagnostic indicators we used mathematical apparatus of ROC analysis.
We investigated too the prognostic significance of PI% for event-free five-year survival (EFS).
Analysis was by Kaplan-Meier.