Keywords:
Extremities, Musculoskeletal bone, Paediatric, Ultrasound, Ultrasound-Colour Doppler, Ultrasound-Spectral Doppler, Statistics, Diagnostic procedure, Arterial access, Haemodynamics / Flow dynamics, Cancer, Image registration
Authors:
I. Begun; Minsk Region/BY
DOI:
10.1594/ecr2013/C-2663
Purpose
Background
In the diagnosis of malignant tumors of the musculoskeletal system a major role plays the methods that allow to visualize the anatomical location and the structure of the tumor,
establish it relationship to the surrounding tissues and organs.
This primarily refers to the X-ray method,
MRI,
and in some cases - the ultrasound [1-5].
However,
in practice,
may be up to 60% of the errors in the initial recognition of malignant bone lesions.
Despite the fact that the known already of the pathogenesis of bone tumors [6-22],
practical approaches to the clinical evaluation of available basic pathophysiological indicators of the blood supply to the tumor and the affected limb,
have not yet been determined.
Of the disadvantages of known methods for the study of neoangiogenesis and pathophysiology in the context of native tumor referred of their invasiveness,
the need for the fence material for morphological studies or administration of the radiopharmaceutical,
and their complexity too,
which currently prevents of their wide practical using for pediatric cancer patients.
Duplex ultrasound with spectral analysis is one of the methods of monitoring the effectiveness of chemotherapy of bone sarcomas,
an affordable,
non-invasive and relatively low cost.
Only in a few studies examined the predictive value of Doppler examination of data for response to preoperative chemotherapy in patients with osteogenic sarcoma and Ewing's sarcoma [23-24].
Purpose. To study the effectiveness of ultrasound for diagnoses and prognostic significance of Doppler pulsatility index (PI) for common femoral artery (CFA) in patients with osteogenic sarcoma (OS) and Ewing's sarcoma (SE).