Keywords:
Tissue characterisation, Technology assessment, MR-Spectroscopy, Oncology, Musculoskeletal soft tissue, Musculoskeletal bone
Authors:
M. Stratta1, T. Robba1, G. Regis1, V. Clementi2, C. Faletti1; 1Turin/IT, 2Bologna/IT
DOI:
10.1594/ecr2013/C-2668
Conclusion
Most MR Spectroscopy studies of musculoskeletal tumors have been focused on increased levels of choline in malignant bone and soft-tissue tumors; choline is a useful marker of malignancy in several organ systems,
for example brain,
breast and prostate.
For soft tissues,
the biologic basis of these observations showing that disorders that influence cell membrane turnover result in changes in the concentration of choline-containing compounds.
These compounds are detectable with MR Spectroscopy as a choline peak at 3.2 ppm
In our trial,
the qualitative results analysis confirmed the feasibility of 1H-MR spectroscopy exam on clinical setting and the possibility to identify the Cho peak on several MSK pathologies.
The ongoing quantitative analysis results,
compared with the histological data,
will help to understand the added value of this technique to the MSK lesion differentiation.