Keywords:
Tissue characterisation, Technology assessment, MR-Spectroscopy, Oncology, Musculoskeletal soft tissue, Musculoskeletal bone
Authors:
M. Stratta1, T. Robba1, G. Regis1, V. Clementi2, C. Faletti1; 1Turin/IT, 2Bologna/IT
DOI:
10.1594/ecr2013/C-2668
Methods and Materials
Between June 2011 and December 2012 we performed MR-spectroscopy sequences in 147 patients (90M,
57 F) with bone and soft tissue lesions.
Our protocol was based on single-voxel point-resolved spectroscopy sequence.
To identify the optimal parameters combination we used several parameters sets including: TR,
TE=35,144,288; NEX and coils.
The volume of interest within lesions was positioned on the areas of early enhancement according to the findings of dynamic contrast-enhanced MR imaging.
(Fig.1-4)
Several methods have evolved for analysis of MR Spectroscopy results.
These methods include qualitative (detection of metabolite peaks) and quantitative (measurement of metabolite ratios relative to noise or to other metabolites) approaches.
The first spectroscopy data evaluation was qualitative,
to identify evident artifacts,
very low quality spectra and a clearly identifiable peak of choline at 3.2 ppm.
The quantitative analysis of the data with LCModel is ongoing.
LCModel may estimate concentrations of minor metabolites.