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Keywords:
Ear / Nose / Throat, Oncology, Head and neck, PET-MR, Diagnostic procedure, Molecular imaging, Cancer, Tissue characterisation
Authors:
M. Gawlitza, S. Purz, A. Boehm, H. Barthel, T. Kahn, O. Sabri, P. Stumpp; Leipzig/DE
DOI:
10.1594/ecr2014/C-0264
Results
17 patients fulfilled all inclusion criteria (15 male,
2 female,
mean age 57.7 ± 7.3 years; range 49 – 79 years,
see Figure 2).
Tumours were 11 primary cancers and 6 recurrent cancers,
located in the oral cavity (n=4),
in the oropharynx (n=8) or in the hypopharynx and larynx (n=5).
In patients with recurrent HNSCC,
mean time from the end of therapy to diagnosis of the recurring carcinoma was 46 months (range from 12 to 120 months).
Comparing primary and recurrent HNSCC,
significantly higher SUVmax (24.41 ± 6.52 vs.
12.93 ± 2.54; p ≤ 0.01) and higher SUVmean values (15.01 ± 4.07 vs.
7.52 ± 1.56; p ≤ 0.01) were observed in de-novo tumours.
Furthermore higher values of Ktrans were observed in primary HNSCC (0.21 ± 0.49 vs.
0.15 ± 0.46; p ≤ 0.01).
The other DCE and DWI values did not differ between both groups (see table 1).
Significant correlations were observed between SUVmax and SUVmean (ρ = 0.988; p ≤ 0.01),
SUVmean and Ktrans (ρ = 0.425; p ≤ 0.05) and kep (ρ = 0.444; p ≤ 0.05); between the microcirculatory parameters Ktrans and kep (ρ = 0.532; p ≤ 0.05) and iAUC (ρ = 0.640; p ≤ 0.01); and between kep and ve (ρ = -0.743; p ≤ 0.01).
Furthermore we noted trends towards an inverse correlation between SUVmax and ADCmin (ρ = -0.352; p = 0.083) and towards a positive correlation between SUVmax and the DCE parameters Ktrans (ρ = 0.37; p=0.072) and kep (ρ = 0.392; p = 0.060).
Also between ADCmean and ADCmin (ρ = 0.364; p = 0.075) and between ADCmean and ve (ρ = 0.401; p = 0.055) trends towards positive correlations were apparent.
Results are additionally depicted in figure 2 and table 2.