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Type:
Educational Exhibit
Keywords:
Geriatrics, Genetic defects, Dementia, Imaging sequences, Diagnostic procedure, MR-Diffusion/Perfusion, MR, Neuroradiology brain, CNS
Authors:
A. Kokunin; Nizhniy Novgorod, Nizhegorodskaya oblast/RU
DOI:
10.1594/ecr2014/C-2348
Findings and procedure details
We use 1.5T MRI (Magnetom Essenza,
Siemens AG,
Medical Solutions,
Magnetic Resonance,
Henkestr.
127,
Erlangen,
Germany) with protocol includes T1/T2-weighted,
T2-FLAIR,
DWI and SWI sequences.
Contrast enhancement is usually not required.
MRI findings includes widespread confluent white matter hyperintensities,
predominantly in the frontal and temporal lobes,
multiple hyperintence lesions in the basal ganglia,
thalamus and pons,
reduction volume of the brain.
Cerebral microhaemorrhages are also often findings without a characteristic distribution.
They were defined as focal areas of signal loss on T2-weighted spin-echo images that were increased in size on SWI (T2*-weighted gradient-echo) images ("blooming effect") (6).
The results of various studies have established that MR imaging abnormalities in CADASIL are associated with clinical disease severity.
Lacunar infarct and global brain atrophy were found to be associated with cognitive dysfunction (1,2),
and WMH,
lacunar infarct,
microbleeding,
and brain atrophy were found to be associated with physical disability (2–5).