Aims and objectives
Background
Liver fibrosis is a reaction of hepatocyte to chronic inflammation and finally liver develops into cirrhosis.
Therefore,Early detection of fibrosis is important to prevent development into cirrhosis,
because cirrhosis is irreversible.
Biopsy is gold standard to evaluate liver fibrosis degree
(Disadvantage of biopsy: Invasiveness,
sampling error,
not repeatable) (1)
MRI is expected as an alternative method.
ADC value
ADC value may reflect the liver fibrosis grade (2-3),
and the reasons are as follows.
Collagen fibers accumulated interstitially restrict proton diffusion.
Reduced perfusion of portal...
Methods and materials
Institutional review board approved this study and informed consent was waived.
Inclusion criteria
Fibrosis grade was confirmed pathologically using surgical resected specimen.
The interval between MRI and operation was within 3 months.
Exclusion criteria
More than 10 nodules in single patient.
After preoperative portal vein embolization or transarterial chemo-embolizaion.
Difficult to evaluate ADC or pathological liver fibrosis grade.
Nodules at lateral segment (got strong influence from heart rate )
Patients
(patients)
104 patients with 115 area were evaluated.
Age: mean 66.4; Men: Female= 72: 32...
Results
ADC value and fibrosis stage
Table 1.
ADC value showed no significant differences between any fibrosis grade.
Spearman's rho between ADC value and fibrosis grade was r = -0.051 and it showed very weak correlation.
Table2.
ADC valuebetween low stage fibrosis(F0-2) and high stage fibrosis(F3-4) showed no signisficant difference.
ADC value calculated on different segmentand fibrosis stage
Table 3.
ADC calculated near the tumor and on different segment showed no significant differences at any fibrosis grade.
Table 4.
ADC value on different segment showed no...
Conclusion
LMR was more useful tool than ADC valueto evaluatefibrosis grade.
ADC value was not useful to evaluate the liver fibrosis grade.
This study revealed no correlation between ADC value and fibrosis grade.
Discussion
ADC value
This study revealed no correlation between ADC value and fibrosis grade,
despiteseveral papers reported that significant correlation was observed between ADC value and the liver fibrosis grade(8).
On the other hand,few paper reported no correlation(9).
The reasons why there were no correlation between liver fibrosis and ADC value may be...
Personal information
1.
Department of Radiology,
Tokyo Medical University,
Japan
T.
L Harada,
K Saito,
N Yoshimura,
Y Araki,S Akata,
K Tokuuye
2.
Department of Anatomic Pathology,
Tokyo Medical University,
Japan
J Matsubayashi,
T Nagao,
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Lewin M,
Poujol RA,
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Luciani A,Vignaud A,et al.Liver Cirrhosis: Intravoxel Incoherent Motion MR Imaging—Pilot Study.Radiology 2008; 249: 891-899
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Tschirch...