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Keywords:
Abdomen, MR-Diffusion/Perfusion, MR, Diagnostic procedure
Authors:
T. L. Harada, K. Saito, J. Mastubayashi, N. Yoshimura, Y. Araki, K. Sugimoto, T. Nagao, S. Akata, K. Tokuuye; Tokyo/JP
DOI:
10.1594/ecr2015/C-1098
Aims and objectives
Background
Liver fibrosis is a reaction of hepatocyte to chronic inflammation and finally liver develops into cirrhosis.
Therefore, Early detection of fibrosis is important to prevent development into cirrhosis,
because cirrhosis is irreversible.
Biopsy is gold standard to evaluate liver fibrosis degree
(Disadvantage of biopsy: Invasiveness,
sampling error,
not repeatable) (1)
MRI is expected as an alternative method.
ADC value
ADC value may reflect the liver fibrosis grade (2-3),
and the reasons are as follows.
- Collagen fibers accumulated interstitially restrict proton diffusion.
- Reduced perfusion of portal vein.(4)
Although the tiny specimen represents the entire liver,
biopsy has been a main method to confirm the fibrosis in previous reports.
Liver to muscle ratio (LMR)
Signal intensity in the hepatobiliary phase may be influenced by several factors,
such as decreased hepatocytes,
deficiency of hepatocyte function.
And this may reflect liver fibrosis (5).
Many studies considered methods to evaluate liver fibrosis.
(6-7)
–Liver-to-muscle ratio
–Liver-to-spleen ratio
–Liver-to-intervertebral disk ratio
Purpose
To evaluate retrospectively whether ADC value and Liver-to muscle ratio (LMR) measured at MRI reflect the fibrosis grade which was evaluated in surgical resected specimen.