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Keywords:
CNS, Neuroradiology brain, MR, Comparative studies
Authors:
H. S. Kim1, J. E. Park2, J. Y. Lee2, S. C. Jung2, C. G. Choi2, S. J. Kim2; 1Seoul, seoul/KR, 2Seoul/KR
DOI:
10.1594/ecr2017/C-2615
Results
The mean DN/P SI ratio difference was not different from zero (P = .08),
even in patients with ≥20 administrations (n = 24).
The mean DN/P SI ratio difference was not associated with any predisposing factors.
However,
the mean GP/Th SI ratio difference decreased (P < .0001),
which was associated with longer mean time interval (P = .012),
number of radiotherapy sessions (P = .018),
and left side of ROI placement (P = .045) on multivariate analysis.
Table: Possible predisposing factors for the mean dentate-to-pons (DN/P) and globus pallidus-to-thalamus (GP/Th) SI ratio difference in various clinical situations
Factors
|
Univariate analysis
|
Multivariate analysis
|
Regression coefficient
|
SE
|
P value
|
Regression coefficient
|
SE
|
P value
|
Mean DN/P SI ratio difference
|
|
|
|
|
|
|
Age
|
-0.004 (-0.050,
0.042)
|
0.023
|
.860
|
|
|
|
Female sex
|
1.055 (-0.164,
2.273)
|
0.619
|
.089
|
|
|
|
Number of administrations
|
0.073 (-0.027,
0.172)
|
0.051
|
.154
|
|
|
|
Mean time interval (TI)
|
0.002 (0.000,
0.004)
|
0.001
|
.055
|
|
|
|
Obtained on 3.0-Tesla MR
|
0.922 (-1.070,
2.913)
|
1.012
|
.036
|
|
|
|
Abnormal renal function
|
0.25 (-2.278,
2.778)
|
1.285
|
.250
|
|
|
|
Abnormal hepatic function
|
0.139 (-1.828,
2.107)
|
1.000
|
.889
|
|
|
|
Whole-brain radiation therapy
|
-0.010 (-1.766,
1.746)
|
0.892
|
.991
|
|
|
|
Number of radiation therapy
|
0.019 (-0.072,
0.111)
|
0.047
|
.679
|
|
|
|
Number of chemotherapy
|
0.037 (-0.017,
0.092)
|
0.028
|
.178
|
|
|
|
Platinum-based chemotherapy
|
0.583 (-0.687,
1.852)
|
0.645
|
.367
|
|
|
|
Measurement at the left side
|
0.540(-0.885,
1.965)
|
0.724
|
.456
|
|
|
|
Mean GP/Th SI ratio difference
|
|
|
|
|
|
|
Age
|
-0.010(-0.041,
0.060)
|
0.026
|
.711
|
|
|
|
Female sex
|
0.223 (-1.126,
1.573)
|
0.686
|
.745
|
|
|
|
Number of administrations
|
-0.139 (-0.249,
-0.030)
|
0.056
|
.013
|
|
|
|
Mean time interval (TI)
|
-0.002 (-0.005,
0.001)
|
0.013
|
.117
|
-0.003 (-0.006,
-0.007)
|
0.013
|
.012
|
Obtained on 3.0-Tesla MR
|
-1.610 (-3.801,
0.582)
|
1.114
|
.149
|
|
|
|
Abnormal renal function
|
0.058 (-2.730,
2.846)
|
1.417
|
.058
|
|
|
|
Abnormal hepatic function
|
-1.827 (-3.986,0.333)
|
1.097
|
.097
|
|
|
|
Whole-brain radiation therapy
|
-0.828 (-2.763,
1.106)
|
0.983
|
.400
|
|
|
|
Number of radiation therapy
|
-0.153 (-0.252,
-0.053)
|
0.051
|
.003
|
-0.127 (-0.231,
-0.022)
|
0.053
|
.018
|
Number of chemotherapy
|
-0.042 (-0.102,
0.019)
|
0.031
|
.175
|
|
|
|
Platinum-based chemotherapy
|
-1.353 (-2.746,
0.041)
|
0.708
|
.057
|
|
|
|
Measurement at the left side
|
-1.630 (-3.192,
-0.069)
|
0.794
|
.041
|
-1.555 (-3.077,
-0.032)
|
0.774
|
.045
|
Note: Data in ( ) are 95% confidence intervals.