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Keywords:
Gastrointestinal tract, Oncology, CT-Quantitative, MR-Diffusion/Perfusion, Staging, Imaging sequences, Technical aspects, Cancer, Tissue characterisation
Authors:
S. Sudarski, T. Floss, U. Attenberger, S. O. Schönberg, T. Henzler; Mannheim/DE
DOI:
10.1594/ecr2017/C-2674
Methods and materials
We prospectively enrolled in an IRB-approved study 12 patients who underwent dVPCT of newly-diagnosed rectal cancer in coloscopy in the framework of metastasis staging with CT.
All patients underwent conventional additional pelvic MR for local staging.
Informed written consent was obtained from all patients.
CT perfusion aquisition parameters:
•2x 192 slice dual-source CT scanner system (Somatom Force,
Siemens,
Healthcare Sector)
•80,
90 or 100 kV tube voltage (170 to 220 mAs)
•50 ml i.v.
contrast (400mg/mL)
•10 sec Bolus
•5ml/s flow
Perfusion analysis:
•ROI-based approach
•Arterial input function (AIF) in external iliac artery/superficial femoral artery
•Analysis of dVPCT data with dedicated software (Body perfusion,
syngo via V30,
Siemens Healthcare Sector)
•Deconvolution model for calculation of perfusion parameters
Investigated quantitative CT perfusion parameters:
- Blood Flow (BF) [ml/100 ml /min]
- Blood Volume (BV) [ml/100 ml]
- Mean Transit Time (MTT) [s]
- Permeability (PERM) [ml/100 ml/ min]
The 4 quantitative CT perfusion parameters BF,
BV,
MTT and PERM were measured two times (M1 and M2 with > 2 weeks between the 2 time points) in the slice rectangular to the rectal cylinder with the biggest area of circumferential tumor burden as ROI.
Paired t-testing was performed and the coefficient of variation from duplicate measurements M1 and M2 was determined to assess reproducibility of dVPCT parameters.