Keywords:
Arteriovenous malformations, Arteriosclerosis, Aneurysms, Arterial access, Angioscopy, Angioplasty, CT-Angiography, Catheter arteriography, CAD, Cardiovascular system, Cardiac, Arteries / Aorta
Authors:
D. J. Petrovic; Belgrade/RS
DOI:
10.1594/ecr2018/C-0185
Methods and materials
Patient population: The number of patients examined was 51,
average age 60 ± 10,
who,
due to acute myocardial infarction with ST elevation (STEMI),
underwent a PCI. Immediately after the intervention and 6 months later,
echocardiographic examinations of anatomical and functional parameters of the left ventricle were carried out,
via the left ventricle mobility index. In the second examination,
the patients were asked to describe their health condition and the occurrences of cardiovascular disorders were monitored (cardiac death,
infarction,
heart failure,
revascularization,
or cerebrovascular stroke).
The study has been accepted by the Ethics Committee of the Clinical Center of Serbia and patients gave informed consent to participate in the study.
Syntax score evaluation: Syntax score is designed as a prognostic tool or a tool that will be based on anatomical findings,
and functional potential importance and clinical implication of occlusion for a certain segment of the coronary arteries (Leaman score),
to predict the occurrence of adverse cardiovascular events. SYNTAX ScoreTM 12 is calculated by analyzing anatomical angiographic variables based on coronarographic recording and quantitative coronary angiography to quantify precisely the lesion. The first three relate to the determination of the dominant coronary artery,
as well as to the arteries and the areas of localized lesions (left descending coronary artery,
the left circumflex artery and the right coronary coronary artery,
and their localization in the coronary artery). The rest of the analysis is related to the presence of total occlusions in blood vessels,
whether the occlusion is longer than 20 mm, the presence of constrictions in a coronary artery as a bifurcation or trifurcation,
the presence of thrombus in the blood vessel (thrombus is visible in angiographic image as a filling defect), the presence of the lesion at the beginning (ostium) of the coronary artery,
the presence of diffused atherosclerosis,
which indicates the presence of over-75-percent constrictions in distal relation to the primary lesion), the presence of winding,
tortuous coronary arteries,
as well as an angiographic detection of calcification in the wall of the coronary artery. Based on this description of the lesion,
presence or absence of certain characteristics,
the program Syntax ScoreTM Calculator 2:02 was designed which,
on the basis of all these variables calculates the numerical value of both angiografic weight and the complexity of coronary lesions,
that is,
Syntax score.
Statistical analysis: The statistical analysis used methods of descriptive statistics,
followed by Student-t test for equal samples and the unbound samples. The comparison of angiographic and clinical variables was conducted by means of Pearson’s correlation.
For determination of prognostic significance,
the variables that were found to be significant by Students t-test for independent samples,
were then tested by means of univariate and multivariate regression analysis,
Statistical significance was set at p<0.05.