Keywords:
MR-Diffusion/Perfusion, MR, Kidney, Abdomen, Diagnostic procedure, Tissue characterisation
Authors:
S. Thiravit, P. Suwanchatree , V. Suvannarerg; Bangkok/TH
DOI:
10.1594/ecr2018/C-1131
Aims and objectives
Diffusion-weighted MR imaging (DWI) can be applied to evaluate kidneys in many clinical aspects,
for instance,
assessment of focal renal masses,
renal insufficiency or chronic kidney disease (CKD),
renal obstruction,
renal artery stenosis as well as evaluation in transplanted kidneys [1-2].
For assessment of chronic kidney disease,
DWI has shown to be an emerging technique to evaluate renal function,
regarding the principle of Brownian motion of water molecules within tissues [1].
The quantitative diffusion measurement is performed using apparent diffusion coefficient (ADC),
which is calculated by at least two different b values and displays information on capillary perfusion and water diffusion [1].
Alteration in perfusion or filtration function of kidneys can be demonstrated on DWI,
resulting decreased ADC values [1-2].
Since,
DWI may be able to identify early renal dysfunction and guide further therapy,
the role of ADC values in evaluation of CKD has recently become an interest of multiple researches [2-5].
In addition,
DWI technique is non-invasive,
safe and no contrast media needed.
Then,
the aim of this study was to evaluate the relationship between apparent diffusion coefficient (ADC) values of renal parenchyma calculated from diffusion-weighted echo-planar MR imaging on 3-T scanners,
and the estimated glomerular filtration rate (eGFR) in patients with chronic kidney disease (CKD).