Aims and objectives
Aim of this study is to validate the use of the pcASL sequence with 1.5 T scanner in the neuroradiological routine in order to obtain perfusion studies in patients who have contraindications to the administration of Gd contrast medium and therefore unable to be studied with the DSCE technique.
pCASL sequence (Pseudo Continuous Arterial Spin Labeling) is the evolution of the less recent PASL (pulsed asl) which was characterized by a pulsed labeling RF with consequent decay of the marked spin signal by virtue of...
Methods and materials
Patients with strongly suspected cerebral glioma were selected on the basis of baseline MR imaging or contrast enhanced and however subsequently confirmed with biopsy or patients with glioma already known in the follow-up phase.
All have been stidied with latest generation 1.5 Tesla RM device.
Investigation protocol included standard study sequences: SE T1,
TSE T2,
TSE FLAIR,
DWI.
Subsequently pCASL sequence was set up after acquiring a TSA PC survey in order to optimally positioni the spin labeling package,
perpendicular to the carotid-vertebral cerebro-afferent vessels....
Results
Survey was conducted on 9 patients but the cases included in the study are 10 in that a patient was also stuedied after therapy.
Based on the answers given by the respondent neuroradiologist,
it was possible to group the cases studied in 3 main categories: positive result with overlap of the findings between both color maps; doubt result; negative outcome with lack of overlap of the findings.
In 8 out of 9 cases,
a good match of the findings was found.
In one case the...
Conclusion
Perfusion study of brain neoplasms without the administration of contrast agent obtainable with the pCASL sequence can be a valid alternative to the most widely used study technique that is DSCE and which provides the administration of GD contrast medium.
In our experience we have been able to evaluate how in case of pathological increase of the perfusion indices,
there is a good overlap of the values deriving from the chromatic maps obtained with the technique without contrast medium pCASL and the chromatic maps obtained...
Personal information
Pollice Saverio MD.
Radiologist c/o Radiology and Neuroradiology Department "L.
Bonomo" Hospital - ASL BT - 76123 Andria BT Italy.
Teaching assignment of Neuroradiology,
High Field MR and Ultrasound 2017/18,
2018/19 c/o UNIFG TSRM.
[email protected] -
[email protected]
References
A.R.
Deibler,
J.
P.
(2008).
Arterial Spin-Labeling in Routine Clinical Practice,
Part 1: Technique and Artifacts.
AJNR Am J Neuroradiol,
Volume 29(7): 1228-34.
AIFA.
(2018,
febraio 12).
Agenzia Italiana Farmaco. Tratto da http://www.agenziafarmaco.gov.it: http://www.agenziafarmaco.gov.it/sites/default/files/NII_DHPC_Gadolinium
Alex M.
Wong,
F.-X.
Y.-L.
(2014).
Comparison of Three-Dimensional Pseudo-continuous Arterial Spin Labeling Perfusion Imaging With Gradient-Echo and Spin-Echo Dynamic Susceptibility Contrast MRI.
Journal of Magnetic Resonance Imaging,
39:427–433.
Bhaswati Roy,
R.
A.
(2013).
Comparative Evaluation of 3-Dimensional Pseudocontinuous Arterial Spin Labeling With Dynamic Contrast-Enhanced Perfusion Magnetic Resonance Imaging in Grading...