Purpose
Background
Gadoxeticacid-enhanced magnetic resonance imaging (MRI) is a standard modality for assessing colorectal liver metastases (CLM) since the hepatobiliary phase (HBP) offers an excellent lesion to liver contrast and increases the lesion detection rate for assessing theresectabilityof liver metastases [1]. The relative liver enhancement (RLE) value on HBP is potentially useful for the MRI assessment of heterogeneous liver function [2-4]. The value of HBP relative tumor enhancement (RTE) is a potential useful biomarker for predicting early treatment response based on tumorheterogeneityinCLMs[5].
Purpose
Textureanalysis was a...
Methods and materials
Patients
Thisprospective study was approved by our institutional review committee, and all patients provided an informed written consent prior to participation. From May 2012 to April2019, Nineteen patients (10males,9females; age range:30-79years; median age:65years)with CLM that underwentpreoperativegadoxeticacid disodium-MRIwithoutchemotherapy in the present study.
Themedian maximum tumor size was2.5cm (range:1.0–6.2) .
Allpatients had a performance status of 0–1.
Methods - MRI Technique
MR images were obtained on 3.0T clinical scanner equipped with a CardiaccoilforT2-weightedimages and Dynamic images.Dynamic images using fat-suppressed T1-weighted gradient-echo images with a three-dimensional (3D) acquisition...
Results
Results
•The entropy of RTE images were positively correlated with the entropy of histology images(Pearson's r = 0.66 ; p = 0.002).(Fig. 4)
•The RTE values and tumor size were not correlated with the entropy of histology images(Pearson's r = 0.32, 0.23 ; p = 0.18, 0.35, respectively). (Fig.5)
Discussion
Theentropy of texture analysis describes a wide range of techniques for quantification of gray-level patterns and pixel inter-relationships within an image providing a measure ofheterogeneity[6].The RTEvalue isa potential useful biomarker for predicting early treatment response...
Conclusion
Conclusion
The entropy of RTE images might be biomarkers based onheterogeneityinCLM.
Personal information and conflict of interest
S. Matsushima; Nagoya/JP - nothing to disclose S. Murata; Nagoya/JP - nothing to disclose Y. Sato; Nagoya/JP - nothing to disclose H. Onaya; Tokyo/JP - nothing to disclose H. Yamaura; Nagoya/JP - nothing to disclose M. Kato; Nagoya/JP - nothing to disclose T. Hasegawa; Nagoya/JP - nothing to disclose H. Ogura; Nagoya/JP - nothing to disclose Y. Inaba; Nagoya/JP - nothing to disclose
References
References
1.Chen L, Zhang J, Zhang L, et al. (2012) Meta-analysis ofgadoxeticacid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the detection of liver metastases.PLoSONE 2012;7:e48681.
2. Matsushima S, Sato Y,YamauraH, et al. Visualization of liver uptake function using the uptake contrast-enhanced ratio in hepatobiliary phase imaging.Magn Reson Imaging. 2014;32:654–659.
doi: 10.1016/j.mri.2014.02.017.
3.KukukGM, Schaefer SG,FimmersR, et al. Hepatobiliary magnetic resonance imaging in patients with liver disease: correlation of liver enhancement with biochemical liver function tests. EurRadiol. 2014;24:2482–2490.
doi: 10.1007/s00330-014-3291-x.
4. Matsushima S, Sato Y,YamauraH, et al. Preoperative...