Keywords:
Performed at one institution, Cross-sectional study, Prospective, Cancer, Diagnostic procedure, Contrast agent-intravenous, MR, Breast
Authors:
N. M. E. M. Settein, S. Abdallah, M. abdel shaheed; Mansoura/EG
DOI:
10.26044/ecr2020/C-03252
Methods and materials
Patient population: Our study included 29 pathologically proven breast cancer cases who didn’t receive any treatment yet, with no general contraindications to MRI and good renal function, the patients’ age ranged from 29 to 65 years ( mean age ± SD = 44.2 ± 9.95 years) .
Data acquisition:
All MRI examinations were performed using 1.5 Tesla device, Conventional MRI study was done (including T1WI, T2WI and fat suppression sequence) as well as dynamic study upon injection of contrast media. Dynamic study consisted of one pre contrast and 5 post contrast series, each of them took about 1.15 minute, the first two contrast-enhanced acquisitions (wash in rate) represented early contrast-enhanced phase while the delayed images (wash out kinetics) represented delayed-phase enhancement. The freehand region of interest (ROI) was placed carefully within the most enhancing part of the lesion. Image post processing was done to produce subtracted images as well as creation of time signal intensity curves.
Data analysis: Lesions were described according to American College of Radiology (ACR) Breast imaging reporting and data system (BIRADS) lexicon 2013 and classified according to morphological appearance into: mass lesions (describing shape, margin and enhancement pattern), non mass enhancement (describing distribution and enhancement pattern) and focus (a tiny dot of enhancement less than 5 mm). Time-signal intensity curves were divided into: type 1 (progressive) curve, type 2 (plateau) curve and type 3 (washout) curve.
The Immunohistochemical profiles of the lesions were obtained and correlated to their morphological criteria.
Statistical analysis:
Data were analyzed using IBM-SPSS (v 16). Student's t-test was used to compare parametric data. Mann-Whitney U- test was used to compare non-parametric data. Inter-group comparison of categorical data was performed by using chi square test (X2-value), results were considered to be statistically significant if p-value ≤ 0.050.