To describe clinical, pathological and imaging findings associated with cerebral amyloid angiopathy (CAA). To show the role of susceptibility-weighted imaging (SWI) in its diagnosis.

INTRODUCTION Cerebral amyloid angiopathy (CAA) is a small vessel disease characterized by deposition of β-amyloid protein within the cerebral arterioles.[1,2] It is unrelated to systemic amyloidosis, being mostly associated with increasing age, Alzheimer's disease, dementia, or post-radiation treatment changes, among others.CAA is an important cause of intracerebral hemorrhage in the elderly. [3,4] EPIDEMIOLOGY AND MANIFESTATIONS Cerebral amyloid deposition occurs in three morphologic varieties, CAA, mass-like and inflammatory.[3,7] CAA is associated with cerebral microhemorrhages in approximately 63 to 73% of cases.[2] These bleeds are typically located...

We describe five cases of CAA. Susceptibility-weighted images (SWI) were performed in all cases, which were all confirmed with histology. Three patients were female. All patients were over 65 years old. Two patients presented with stroke-like symptoms, while the other three presented one each with seizure, altered mental status, andrapid cognitive impairment. MR Imaging evaluation showed one patient with edema without hemorrhage [ Fig. 1, Fig. 10 ]; four patients with lobar hemorrhage [Fig. 5](two of them had “code stroke”[Fig. 7]presentations, both requiring decompressive surgery)....

The clinicians should be aware of the varied imaging appearence of CAA. Diffuse lobar vasogenic edema or mass-like non-enchancing white matter T2 hyperdensities in CAA, may mimic low-grade infiltrative glioma or gliomatosis. SWI can easily be included in routine neuroimaging protocols, especially in stroke and head trauma imaging protocols. SWI identified many more microhemorrhages than conventional techniques, which often led to earlier diagnosis and treatment response on patients with CAA. Improved detection of microhemorrhage may become increasingly important in the diagnosis, management, and monitoring of...

K. Sotomayor; Augusta, GA/US - nothing to disclose M. Negrotto; Montevideo/UY - nothing to disclose R. Figueroa; Augusta, GA/US - nothing to disclose A. Bonilla; Lima/PE - nothing to disclose S. Forseen; Augusta, GA/US - nothing to disclose B. Gilbert; Augusta, GA/US - nothing to disclose G. Palacios; Augusta, GA/US - nothing to disclose F. Bustamante; Augusta, GA/US - nothing to disclose C. Scelsi; Augusta, GA/US - nothing to disclose

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