Retrospective evaluation of HCM patients with and without myocardial edema.

Congress:

ECR 2020

Poster Number:

C-11556

Type:

Scientific Exhibit

Keywords:

Cardiac, MR, Comparative studies, Inflammation, Retrospective, Case-control study, Not applicable

Authors:

R. palumbo¹, D. De Stefano², V. Cirimele², A. tamburrano³, M. Luzietti⁴, V. BUFFA³, B. Beomonte Zobel²; ¹roma, italia/IT, ²Rome/IT, ³roma/IT, ⁴Roma (RM)/IT

DOI:

10.26044/ecr2020/C-11556

DOI-Link:

https://dx.doi.org/10.26044/ecr2020/C-11556

Fig. 6: The image shows the significance of the results obtained;

Fig. 7: the graph shows the inversely proportional relationship between FE and LE...

Fig. 9: the graph shows a directly proportional relationship between Stir positive...

Fig. 8: the graph shows the directly proportional relationship between the LE segments...

Purpose

our study aims to evaluate the existence of a correlation between the presence of myocardial edema (indicated by the pathological hyperintensity in T2 STIR sequences), left ventricular function (assessed by post-processing analysis with Syngovia software), presence and extent of myocardial damage (evaluated with the Late Gadolinium Enhancment sequences) and risk of sudden cardiac death in patients with hypertrophic cardiomyopathy.

Methods and materials

67 Cardiac Magnetic Resonance Imaging (CMR) was retrospectively evaluated of Patients with Hypertrophic Cardiomyopathy undergoing treatment at the U.O.C. of Cardiology (Cardiomyopathy Clinic) of the "San Camillo Forlanini" Hospital in Rome, carried out in the period from January 2017 to October 2018 at the U.O. Cardiovascular Radiology (Cardioscience Department) of the A.O.: "San Camillo Forlanini" in Rome.The Cardiac Magnetic Resonance Imaging (CMR) were performed with 1.5 T Magnet (Siemens Magnetom Avanto), using the following study protocol: • Cine - SSFP cardiac axes (2 chambers, 4...

Results

among the 67 Patients examined, 12 (18%) tested positive for myocardial edema; a significant reduction in the ejection fraction was observed in this subgroup compared to patients with negative T2-STIR (63% ± 6 vs 77% ± 10, p

Conclusion

The presence and extent of myocardial edema in HCM Patients shows a direct correlation with the degree of myocardial fibrosis and an inverse correlation with the ejection fraction. A higher average frequency of TVNS episodes and a higher risk profile for SD are observed in patients with myocardial edema. The presence of myocardial edema in HCM identifies a subgroup of individuals with a more unfavorable prognosis, with consequent implications for the follow-up and therapeutic management of these patients.

Personal information and conflict of interest

R. Palumbo; Rome, ITALIA/IT - Author at Scuola di Specializzazione in Radiodiagnostica, Università Campus Bio-Medico di Roma. D. de Stefano; Rome/IT - Author at Scuola di Specializzazione in Radiodiagnostica, Università Campus Bio-Medico di Roma. V. Cirimele; Rome/IT - Author at Scuola di Specializzazione in Radiodiagnostica, Università Campus Bio-Medico di Roma. M. Luzietti; Roma (RM)/IT - Author at U.O.C. Diagnostica per Immagini – Elezione, Azienda Ospedaliera San Camillo- Forlanini, Roma V. Buffa; Rome/IT - Author at U.O.C. Diagnostica per Immagini – Elezione, Azienda Ospedaliera San Camillo-...

References

·Abnormal T2-STIR magnetic resonance in hypertrophic cardiomyopathy: a marker of advanced disease and electrical myocardial instability. Todiere G,Pisciella L,Barison A,Del Franco A,Zachara E,Piaggi P,Re F,Pingitore A,Emdin M,Lombardi M,Aquaro GD; ·A novel clinical risk prediction model for suddencardiac death in hypertrophic cardiomyopathy(HCM Risk-SCD). Constantinos O’Mahony, Fatima Jichi, Menelaos Pavlou, Lorenzo Monserrat, Aristides Anastasakis, Claudio Rapezzi, Elena Biagini, Juan Ramon Gimeno, Giuseppe Limongelli, WilliamJ. McKenna, Rumana Z.Omar, and Perry M. Elliott, for the Hypertrophic Cardiomyopathy Outcomes Investigators; ·High signal intensity on T2-weighted cardiac magnetic resonance imaging correlates...