Learning objectives
Determine the spectrum of findings on chest computed tomography (CT) in patients with hematological malignancies.
Background
Leukemia, lymphoma and myeloproliferative diseases are group of hematological malignancies that make patients susceptible to pulmonary complications (PC). PC of hematological malignancies and their treatments are common causes of morbidity and mortality. Abnormal vital signs (fever, hypoxemia) and respiratory symptoms such as dyspnea, cough, hemoptysis and chest pain bring patients to chest imaging. PC can be broadly categorized as:
A.Infectious (caused by bacteria, viruses, fungi and parasites)
B.Malignant (primary involvement, relapse/ recurrence)
C.Toxic (drug and radiation toxicity)
D.“Others”[1]
Pulmonary complications are radiologicaly manifested on computed...
Findings and procedure details
For the past 3 years we preformed chest CT among 20 patients with known hematological malignancies, due to respiratory symptoms or for follow up. 13 patients had positive chest CT findings. There were 7 males and 6 females, the average age at the time of examination was 50,9±14,2. We analyzed the presence of nodular lesion, consolidation, cavitation, ground-glass lesion, interstitial thickening, lymphadenopathy and pleural involvement (effusion and pleural masses) (Table 1).
CT findings
Number of patients
Nodular lesion
5
Consolidation
7
Cavitation
4
Ground-glass lesion...
Conclusion
In patients with hematological malignancies, integrated clinic-radiologic approach can help in differentiation of pulmonary complications in order to provide more accurate therapy and improve overall patient outcome.
Personal information and conflict of interest
L. Pajic; Belgrade/RS - Speaker at n/a - Author at n/a A. Petkovic; Belgrade/RS - Author at n/a N. Menkovic; Belgrade/RS - Author at n/a M. Ilic; Belgrade/RS - Author at n/a D. Cosic; Belgrade/RS - Author at n/a R. Maksimovic; Belgrade/RS - Author at n/a
References
1. Bianca Harris, MD, MSc,Alexander I. Geyer, MD.Diagnostic Evaluation of Pulmonary Abnormalities in Patients with Hematologic Malignancies and Hematopoietic Cell Transplantation. 2016. DOI: 10.1016/j.ccm.2016.12.008
2.Girish S. Shroff, MD Mylene T. Truong, MD Brett W. Carter, MD Marcelo F. Benveniste, MD Rashmi Kanagal-Shamanna, MD Greg Rauch Chitra Viswanathan, MD Prajwal C. Boddu, MD Naval Daver, MD Carol C. Wu, MD.Leukemic Involvement in the Thorax.RadioGraphics 2019; 39:44–61
3.Arlene Sirajuddin, MD Kirtee Raparia, MBBS Vanessa A. Lewis, MD Teri J. Franks, MD Sabeen Dhand, MD Jeffrey R. Galvin,...