Male breast cancer is rare, accounting for less than 1% of all cancers in men and less than 1% of all breast cancers [1]. It is usually unilateral; only 1% is bilateral [2]. Low incidence rate in men is due to relatively low amount of breast tissue and a different hormonal status than women [3]. Male patients are frequently at a higher age (5-10 years older; peak incidence at 67 years) and at higher stage than female at breast cancer diagnosis [3]. For the last...

A retrospective analysis of all male patients examinated at our Breast Center from 2015 to 2020 was conducted. We reviewed our database of 461 male patients (mean age 66 years) who presented for palpable mass or were in follow-up for breast cancer (13 of them). Our center diagnostic work-up includes clinical assessment, radiologic assessment (mammography and ultrasound examination), and, in suspicious or indeterminate masses (BI-RADS 4-5), core biopsy.

Of 406 patients, 339 (84%) had mono/bilateral gynecomastia, 21 (5%) were asymptomatic or presented with a benign lesion (lipoma, pseudo-gynecomastia, cyst or inflammation), 46 (11%) underwent biopsy (50 biopsies in total) for suspicious or highly suggestive of malignancy lesions (BI-RADS 4 -5). Of the last group, 26/46 (57%) had a benign lesion while 20/46 (43%) had a malignant breast cancer. The benign lesions were 18 gynecomastia, 2 tubular fibro-adenomatosis, 1 fibro-myolipoma, 1 intraductal papilloma, 1 inflammation, 1 fibrosis and 2 a rare benign tumor: Abrikossoff...

According to literature, we have seen an increase in male breast examinations, most for gynecomastia, and an increase of incidence of male breast cancer [4]: 40% (N= 8/20) of our male breast cancer was diagnosed in 2019 (in 2020, cause SARS-CoV2 pandemia, we had few male access numbers). Left breast was more frequently involved, as reported by literature [3]. Although invasive ductal carcinoma is the most common histologic subtype of male breast cancer (approximately 85% of breast cancer cases in men), we found several cases...

C. Marchetti: Nothing to disclose M. C. Torrione: Nothing to disclose i. sallese: Nothing to disclose v. marisi: Nothing to disclose A. Di Credico: Nothing to disclose M. Muzi: Nothing to disclose M. Caulo: Nothing to disclose

Chesebro AL, Rives AF, Shaffer K. Male Breast Disease: What the Radiologist Needs to Know. Curr Probl Diagn Radiol. 2019 Sep-Oct;48(5):482-493. doi: 10.1067/j.cpradiol.2018.07.003. Epub 2018 Jul 29. PMID: 30122313. Nguyen C, Kettler MD, Swirsky ME, Miller VI, Scott C, Krause R, Hadro JA. Male breast disease: pictorial review with radiologic-pathologic correlation. Radiographics. 2013 May;33(3):763-79. doi: 10.1148/rg.333125137. PMID: 23674773. Yalaza M, İnan A, Bozer M. Male Breast Cancer. J Breast Health. 2016 Jan 1;12(1):1-8. doi: 10.5152/tjbh.2015.2711. PMID: 28331724; PMCID: PMC5351429. Leon-Ferre RA, Giridhar KV, Hieken TJ,...