Multiple myeloma (MM) is the second most common hematological malignancy and is based on a cytogenetically heterogeneous proliferative disorder of clonal plasma cells.
Although it can affect different organs,
the bone skeleton is highlighted both in terms of prevalence and clinical impact.
Despite the striking advances in MM therapy,
bone disease can remarkably affect the patient’s quality of life (1).
Many imaging techniques have been proposed for the detection of MM skeletal involvement (1),
but computed tomography (CT) was the one that has been included...
Description of activity and work performed
In the study were included patients with MM diagnosed (were selected patients in the third stage of the disease,
known with plasmacytomas confirmed by biopsy,
symptomatic and during treatment,
at which imaging controls are performed at about 6-12 months) who were evaluated by WBLDCT exam,
in a single spiral acquisition covered the skull to the femoral bones,
followed by processing in sagittal and coronal reconstructions in a bone and soft tissue windows and of course,
Typical features of MM were analyzed on...
Conclusion and recommendations
WBLDCTis a rapid,
robust and accessible technique for the diagnostic of MM beingan alternative imaging modality to standard bone X-ray/ standard CT evaluation or MRI,
with a good quality concerning the assessment of typical multiple myeloma features at much lower radiation doses in comparison to standard CT protocol.
mail: [email protected]
Medical Imaging and Interventional Radiology Department
Fundeni Clinical Institute,
UMPh Carol Davila,
Ferrari et al “Myeloma bone and extra-medullary disease: Role of PET/CT and otherwhole-body imaging techniques”,
Critical Reviews in Oncology/Hematology 101 (2016) 169–183.
A.Urbanik et al “Whole-Body Low-Dose Computed Tomography (WBLDCT) in Assessment of Patients with Multiple Myeloma – Pilot Study and Standard Imaging Protocol Suggestion”,
Polish Journal of Radiology,
2017; 82: 356-363.
Barrington et al “Guidelines for the use of imaging in the management of patients with myeloma",
British Journal of...