Aims and objectives
Using a 5-point Deauville scale suggests a visual or semi-quantitative comparison of 18F-fluorodeoxyglucose (18F-FDG) accumulation in metabolically active pathological foci with reference tissues - the surrounding background,
mediastinal blood pool or liver.
In the semi-quantitative analysis 18F-FDG standardized uptake value (SUV) is calculated [1].
Our aim was to analyze interpretation of whole body positron emission tomography with 18F-FDG combined with X-ray computed tomography (PET/CT) in patients with lymphoma after completion of chemotherapy (ChT),
to assess reproducibility of established categories and prognostic properties of Deauville scale,...
Methods and materials
This is a retrospective study of 89 patients with lymphoma who underwent whole body (WB)PET/CT after completion of ChT during 2015-2017 in Republican Center of Positron Emission Tomography.
Hodgkin lymphoma (HL) occurred in 34 people,
non-Hodgkin lymphoma (NHL) in 55.
All patients were observed for at least 6 months after PET/CT.
The interval from the completion of ChT until the PET/CT was 41±29 days.
Preparation of the patient included fasting for at least 6 h and restriction of physical activity during the day before the...
Results
Stages of lymphoma were distributed as follows: stage I - 5 patients,
II - 28,
III - 21,
IV - 35.
The number of ChT courses was from 3 to 8.Additional treatment after PET/CT was performed in 46 (52%) patients,
including 20 with LH and 26 with NHL.
Examples of the establishment of Deauville categories 1-5 are shown in Figure 1.
First of all,
in the analysis of PET/CT images,
the foci of physiological and non-tumor 18F-FDG accumulation were excluded.
The exact differentiation was difficult...
Conclusion
1.
The high reproducibility of the Deauville categories established by different physicians was proved in 18F-FDG PET/CT studies performed in patients with lymphoma after ChT,
which is consistent with data from other studies [6].
2.
The non-specific 18F-FDG accumulation in organs and tissues (sarcoidosis,
inflammatory foci in the lungs,
reactive lymph nodes) can lead to false positive PET findings.
Diffuse 18F-FDG accumulation in the bone marrow may be a result of its activation after ChT and shouldn't be regarded as a lesion [2].
3.
PFS...
References
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Role...