Keywords:
CNS, Neuroradiology brain, MR, MR-Diffusion/Perfusion, Education, AIDS, Infection, Inflammation
Authors:
S. Gerevini, P. cinque; Milan/IT
DOI:
10.26044/ecr2019/C-1295
Methods and materials
We retrospectively analyzed radiological,
clinical and virological data of 21 HIV-infected patients with CSF escape encephalitis,
i.e.,
incident neurological symptoms while on ART (>9 months) and detectable CSF HIV-RNA with concomitant,
undetectable plasma HIV-RNA,
or CSF HIV-RNA higher than in plasma,
and in 17 patients with classical HIV-E. Although all patients were analyzed retrospectively and not all have done MRI in our center we considered for the morphologic evaluation presence of signal alteration in T1,
T2 FLAIR and DWI sequences.
For these reasons MR images were totally disposable for 19 esc HIV encephalitis and 16 classical HIV encefalitis.
We made a functional evalutation of patients studied in our centre with measurements of DWI and ADC values positioning a region of interest in centra semiovalia bilaterally (two rois),
corpus callosum,
corticospinal tracts,
and cerebellum for references.
We made a measurements for all group of patients both at onset and during follow up.
We considered an evaluation of a group of normal subjects matched for age and we also consider and evaluation of a comparison group of HIV infected patients without any kind of presence (both clinical and/or liquoral) of HIV related disease.
All patients were studied on 1.5 Tesla equipment.
This study was approved by the Ethical Committee of our Institute and patients gave written permission to use clinical data for research purposes.