Keywords:
CNS, Neuroradiology brain, MR, MR-Diffusion/Perfusion, Education, AIDS, Infection, Inflammation
Authors:
S. Gerevini, P. cinque; Milan/IT
DOI:
10.26044/ecr2019/C-1295
Conclusion
Despite similarities in clinical presentations,
specific MRI and CSF findings were observed in esc-HIVE compared to pre-cART HIVE in particular the presence of frequent inflammatory pattern at MRI,
with no atrophy.
Primarily diffuse periventricular white matter hyperintensity,
CSF escape differed from classical HIV-E for a more frequent involvement of corpus callosum,
cerebellar regions and brainstem and,
more in general,
for the presence of reversible edema with mass effect.
From a viral point of view lower CSF levels of HIV replication and higher CSF cell numbers and proteins levels,
but lower levels of suPAr,
as markers of macrophage activation.
These findings suggest different underlying mechanisms between the two entities,
with esc-HIVE associated with lower extent of HIV replication and presence of inflammatory response in the CNS.